Prevalence of Maternal HIV Infection in Scotland Based on Unlinked Anonymous Testing of Newborn Babies. Update

1993 ◽  
Vol 38 (1) ◽  
pp. 16-17 ◽  
Author(s):  
D.M. Tappin ◽  
R.W.A. Girdwood ◽  
E.A.C. Follett ◽  
R. Kennedy ◽  
A.J. Brown ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Dried Blood Spots ◽  
Enzyme Linked Immunosorbent Assay ◽  
Anonymous Testing ◽  
Unlinked Anonymous Testing ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Childbearing Women ◽  
Guthrie Cards ◽  
Hiv 1

In January 1990, unlinked anonymous testing of Guthrie cards for HIV antibody commenced in Scotland. Ethics Committee approval allowed testing of 99.6% of Scottish births. Twenty-one mothers spontaneously refused to allow testing of their baby's blood. Samples were coded by district postcodes. For 1990 through 1991, eluates of 132,531 dried blood spots were initially tested for HIV-1 antibody with the Fujirebio technique. Of the 49 positive samples 38 were confirmed to be positive by enzyme-linked immunosorbent assay and western blot (seroprevalence 0.3 per 1000). Thirty-five of 38 samples came from large metropolitan areas in Scotland. Prevalences were 2.0 per 1000 for Edinburgh city, 0.7 per 1000 for Dundee and Aberdeen, 0.15 per 1000 for Glasgow and 0.05 per thousand for all other areas in Scotland. Recent spread of HIV infection to Aberdeen may have occurred. These figures do not support an overall increase of HIV infection in childbearing women in Scotland.

Prevalence of maternal HIV infection in Scotland based on unlinked anonymous testing of newborn babies

The Lancet ◽  
1991 ◽  
Vol 337 (8757) ◽  
pp. 1565-1567 ◽  
Author(s):  
F. Cockburn ◽  
D.M. Tappin ◽  
R.W.A. Girdwood ◽  
R. Kennedy ◽  
A.J. Brown ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Anonymous Testing ◽  
Unlinked Anonymous Testing ◽  
Maternal Hiv ◽  
Maternal Hiv Infection

Prevalence of maternal HIV infection based on unlinked anonymous testing of newborn babies

The Lancet ◽  
1990 ◽  
Vol 335 (8688) ◽  
pp. 516-519 ◽  
Author(s):  
C.S Peckham ◽  
A.E Ades ◽  
C O'Connor ◽  
R.S Tedder ◽  
M Briggs ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Anonymous Testing ◽  
Unlinked Anonymous Testing ◽  
Maternal Hiv ◽  
Maternal Hiv Infection

Prevalence of maternal HIV infection based on anonymous testing of neonates, Sydney 1989

1990 ◽  
Vol 153 (7) ◽  
pp. 383-386 ◽  
Author(s):  
Mary‐Louise McLaws ◽  
David A Cooper ◽  
Andrew R D Brown ◽  
Bridget Wilcken ◽  
Phillip H. Cunningham ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Anonymous Testing ◽  
Maternal Hiv ◽  
Maternal Hiv Infection

RISK FOR PERINATAL HIV-1 TRANSMISSION ACCORDING TO MATERNAL IMMUNOLOGIC, VIROLOGIC, AND PLACENTAL FACTORS

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 275-276
Author(s):  
Joseph Church
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Hiv Transmission ◽  
Perinatal Hiv ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
The Impact ◽  
Hiv 1

Subgroups of HIV-infected women based upon maternal immunologic and placental characteristics had a risk of perinatal HIV transmission that varied from 7% to 71%. The impact of different risk factors for perinatal HIV vary over the course of maternal HIV infection.

The impact of maternal HIV infection on parenting in inner-city African American families.

1997 ◽  
Vol 11 (4) ◽  
pp. 447-461 ◽  
Author(s):  
Beth A. Kotchick ◽  
Rex Forehand ◽  
Gene Brody ◽  
Lisa Armistead ◽  
Patricia Simon ◽  
...  
Keyword(s):  
African American ◽  
Hiv Infection ◽  
Inner City ◽  
African American Families ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
The Impact ◽  
American Families

Maternal HIV infection and spontaneous versus provider-initiated preterm birth in an urban Zambian cohort

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Joan T PRICE ◽  
Bellington VWALIKA ◽  
Jessie K EDWARDS ◽  
Stephen R COLE ◽  
Margaret P KASARO ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Hiv Infection ◽  
Maternal Hiv ◽  
Maternal Hiv Infection

scholarly journals Streptavidin-conjugated gold nanoclusters as ultrasensitive fluorescent sensors for early diagnosis of HIV infection

2018 ◽  
Vol 4 (11) ◽  
pp. eaar6280 ◽  
Author(s):  
Aditya Dileep Kurdekar ◽  
L. A. Avinash Chunduri ◽  
C. Sai Manohar ◽  
Mohan Kumar Haleyurgirisetty ◽  
Indira K. Hewlett ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Limit Of Detection ◽  
Gold Nanoclusters ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dependent Manner ◽  
Metal Nanoclusters ◽  
Detection Range ◽  
In Silico Studies ◽  
P24 Antigen ◽  
Hiv 1

We have engineered streptavidin-labeled fluorescent gold nanoclusters to develop a gold nanocluster immunoassay (GNCIA) for the early and sensitive detection of HIV infection. We performed computational simulations on the mechanism of interaction between the nanoclusters and the streptavidin protein via in silico studies and showed that gold nanoclusters enhance the binding to the protein, by enhancing interaction between the Au atoms and the specific active site residues, compared to other metal nanoclusters. We also evaluated the role of glutathione conjugation in binding to gold nanoclusters with streptavidin. As proof of concept, GNCIA achieved a sensitivity limit of detection of HIV-1 p24 antigen in clinical specimens of 5 pg/ml, with a detection range up to1000 pg/ml in a linear dose-dependent manner. GNCIA demonstrated a threefold higher sensitivity and specificity compared to enzyme-linked immunosorbent assay for the detection of HIV p24 antigen. The specificity of the immunoassay was 100% when tested with plasma samples negative for HIV-1 p24 antigen and positive for viruses such as hepatitis B virus, hepatitis C virus, and dengue. GNCIA could be developed into a universal labeling technology using the relevant capture and detector antibodies for the specific detection of antigens of various pathogens in the future.

scholarly journals Obstetric and new born outcome in HIV infected pregnant women: a prospective cohort study in Bangalore Medical College Hospitals, India

2018 ◽  
Vol 7 (11) ◽  
pp. 4445
Author(s):  
Rashmi S. Desai ◽  
Geetha Shivamurthy ◽  
Sameer Desai
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Hiv Infection ◽  
Pregnant Women ◽  
Opportunistic Infection ◽  
Prospective Cohort ◽  
Premature Rupture ◽  
Maternal Hiv ◽  
Maternal Hiv Infection ◽  
Cd4 Cell

Background: The effect of HIV on obstetric complications is known to vary across regions of world. The variation may be due to HIV infection per se or it may be due to complex interaction of related medical and social conditions that affect pregnancy. Incidence of these obstetric complications in HIV infected pregnant women is not well reported in India. So, this prospective cohort study was carried to observe the demographics and incidence of obstetrics complications like abortions, still birth, premature rupture of membranes, preterm delivery, opportunistic infections in HIV infected pregnant women.Methods: All pregnant women who were screened positive for HIV test, irrespective of their gestational age were included in the study. Apart from routine obstetric care, CD4 cell count was carried out. The patients were followed up till term, delivery and up to 6-week postpartum period. Obstetric outcomes like incidence of abortion, intrauterine death, preterm delivery and premature rupture of membrane were noted. Baby`s birth weight and the incidence of maternal opportunistic infection were noted and correlated with maternal CD4 cell count.Results: Maternal HIV infection is associated pre-term labour in 34.5%, PROM in 30%, low birth weight in 52.3%. Increased incidences of these adverse outcomes have an inverse relationship with CD4 count.Conclusions: Maternal HIV infection is associated with increased incidence of adverse obstetric outcome and opportunistic infection, and their incidences increase with lower CD4 count.

Sign in / Sign up

Export Citation Format

Share Document