Peptide synthesis by proteases in organic solvents: Medium effect on substrate specificity

1992 ◽  
Vol 14 (10) ◽  
pp. 842-847 ◽  
Author(s):  
Tohru Nagashima ◽  
Akira Watanabe ◽  
Hideo Kise
1987 ◽  
Vol 109 (12) ◽  
pp. 3802-3804 ◽  
Author(s):  
Alexey L. Margolin ◽  
Alexander M. Klibanov

1997 ◽  
Vol 20 (8) ◽  
pp. 623-628 ◽  
Author(s):  
Maria V. Sergeeva ◽  
Vikram M. Paradkar ◽  
Jonathan S. Dordick

1987 ◽  
Vol 42 (4) ◽  
pp. 455-460 ◽  
Author(s):  
Ernst Bayer ◽  
Heribert Hellstern ◽  
Heiner Eckstein

Abstract Polystyrene-polyoxyethylene craft copolymers have been used for step-wise peptide synthesis. After completion of synthesis the protecting groups are cleaved under acidic conditions, where the polymer-peptide bond is stable. These gels in comparison to polystyrene peptide gels, show better properties for applications in affinity chromatography as well as synthesis on solid supports, because the advantageous properties of polystyrene beads are combined with the excellent spacer behavior of polyoxyethylene chains (mobility, solvation by water and organic solvents). Peptide gels with polylysine sequences have been synthesized as highly selective stationary phases for the separation of the homologous oligo desoxyribonucleotides (dT)n with n = 1-3. The principal possibilities of these gels for affinity chromatography is demonstrated.


1997 ◽  
Vol 36 (22) ◽  
pp. 2473-2475 ◽  
Author(s):  
Frank Bordusa ◽  
Dirk Ullmann ◽  
Christian Elsner ◽  
Hans-Dieter Jakubke

1986 ◽  
Vol 108 (10) ◽  
pp. 2767-2768 ◽  
Author(s):  
Aleksey. Zaks ◽  
Alexander M. Klibanov

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