Inflammatory cells and mediators in the silicone chamber model for nerve regeneration☆

Biomaterials ◽  
1993 ◽  
Vol 14 (15) ◽  
pp. 1180-1185 ◽  
Author(s):  
N DANIELSEN ◽  
L DAHLIN ◽  
P THOMSEN
Keyword(s):  
Nerve Regeneration ◽  
Inflammatory Cells ◽  
Chamber Model

scholarly journals Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Carlos Rodrigo Camara-Lemarroy ◽  
Emmanuel Irineo Gonzalez-Moreno ◽  
Francisco Javier Guzman-de la Garza ◽  
Nancy Esthela Fernandez-Garza
Keyword(s):  
Arachidonic Acid ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Inflammatory Cells ◽  
Nerve Degeneration ◽  
Activation Of Transcription ◽  
Local Signaling ◽  
Axonal Degradation ◽  
Subsequent Regeneration ◽  
Arachidonic Acid Derivatives

After peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD). This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflammatory mediators such as cytokines, chemokines, and the activation of transcription factors also related to the inflammatory response. Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes. The enzymes responsible for their production, cyclooxygenases and lipooxygenases, also participate in nerve degeneration and regeneration. The interactions between signals for nerve regeneration and neuroinflammation go all the way down to the molecular level. In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise.

Glial and Neuronal Marker Proteins in the Silicone Chamber Model for Nerve Regeneration

1993 ◽  
Vol 60 (3) ◽  
pp. 1098-1104 ◽  
Author(s):  
J.-E. Karlsson ◽  
L. E. Rosengren ◽  
S. Wang ◽  
N. Danielsen ◽  
K. G. Haglid
Keyword(s):  
Nerve Regeneration ◽  
Neuronal Marker ◽  
Marker Proteins ◽  
Chamber Model

The effects of delayed nerve repair on nerve regeneration in a silicone chamber model

1994 ◽  
Vol 6 (4) ◽  
pp. 317-322 ◽  
Author(s):  
Nils Danielsen ◽  
Bengt R. Johansson ◽  
Lars B. Dahlin
Keyword(s):  
Nerve Regeneration ◽  
Nerve Repair ◽  
Chamber Model

A two-compartment modification of the silicone chamber model for nerve regeneration

1988 ◽  
Vol 99 (3) ◽  
pp. 622-635 ◽  
Author(s):  
Nils Danielsen ◽  
H.Lee Vahlsing ◽  
Marston Manthorpe ◽  
Silvio Varon
Keyword(s):  
Nerve Regeneration ◽  
Chamber Model

Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model

1988 ◽  
Vol 20 (3) ◽  
pp. 320-330 ◽  
Author(s):  
N. Danielsen ◽  
B. Pettmann ◽  
H. L. Vahlsing ◽  
M. Manthorpe ◽  
Silvio Varon
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Chamber Model

Experimental Nerve Regeneration

1991 ◽  
Vol 24 (3) ◽  
pp. 739-752 ◽  
Author(s):  
Brian J.F. Wong ◽  
Douglas E. Mattox
Keyword(s):  
Nerve Regeneration
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