Responses of single units in the inferior olive nucleus to stimulation of the splanchnic afferents in the cat

1980 ◽  
Vol 2 (1) ◽  
pp. 15-22 ◽  
Author(s):  
J. Perrin ◽  
J. Crousillat
Keyword(s):  
Inferior Olive ◽  
Single Units ◽  
Stimulation Of

Responses of single units in cerebellar vermis of the cat to monaural and binaural stimuli

1975 ◽  
Vol 38 (2) ◽  
pp. 418-429 ◽  
Author(s):  
L. M. Aitkin ◽  
J. Boyd
Keyword(s):  
Inferior Colliculus ◽  
Cochlear Nucleus ◽  
Single Units ◽  
Intensity Difference ◽  
Cerebellar Neurons ◽  
Monaural Stimulation ◽  
Sustained Responses ◽  
Maximal Discharge ◽  
Onset Responses ◽  
Stimulation Of

The responses of 146 cerebellar neurons to tone stimuli were studied in 29 cats anesthetized with chloralose-urethan and in 7 decerebrate preparations. Units were classified as onset or sustained firing. Onset spikes occurred on stimulation of either ear and showed binaural facilitation, while sustained discharges were frequently only excited by monaural stimulation. The latent periods of sustained discharges appeared to be shorter than those of onset responses, and sustained discharges were also more sharply tuned than the onset units. Evidence was presented suggesting that onset responses reflected input from the inferior colliculus and sustained responses, the cochlear nucleus. The sterotyped facilitatory behavior of onset units suggested that a maximal discharge might occur if sounds were of equal intensity at each ear; 26 neurons were examined with variable interaural time or intensity differences and 10 of these exhibited maximal firing when the interaural time and intensity difference was zero--i.e., if the sound was located directly in front of the head.

Red Nucleus Stimulation Inhibits Within the Inferior Olive

1998 ◽  
Vol 80 (6) ◽  
pp. 3127-3136 ◽  
Author(s):  
K. M. Horn ◽  
T. M. Hamm ◽  
A. R. Gibson
Keyword(s):  
Inferior Olive ◽  
Red Nucleus ◽  
Salient Feature ◽  
Cutaneous Stimulation ◽  
Motor Pathways ◽  
Peripheral Stimulation ◽  
Dorsal Columns ◽  
Dorsolateral Funiculus ◽  
Somatosensory Responses ◽  
Stimulation Of

Horn, K. M., T. M. Hamm, and A. R. Gibson. Red nucleus stimulation inhibits within the inferior olive. J. Neurophysiol. 80: 3127–3136, 1998. In the anesthetized cat, electrical stimulation of the magnocellular red nucleus (RNm) inhibits responses of rostral dorsal accessory olive (rDAO) neurons to cutaneous stimulation. We tested the hypothesis that RNm-mediated inhibition occurs within the inferior olive by using stimulation of the ventral funiculus (VF) of the spinal cord in place of cutaneous stimulation of the hindlimb. Fibers in the VF terminate on hindlimb rDAO neurons, so inhibition of this input would have to occur within the olive. rDAO responses elicited by VF stimulation were inhibited by prior stimulation of the RNm, indicating that inhibition occurs within the olive. In contrast, evoked potentials recorded from the VF or dorsal columns following hindlimb stimulation were not affected by prior stimulation of RNm, indicating that stimulation of the RNm does not inhibit olivary afferents at spinal levels. RNm stimulation that inhibited rDAO responses had little effect on evoked somatosensory responses in thalamus, indicating that inhibition generated by activity in RNm may be specific to rDAO. To test limb specificity of RNm-mediated inhibition, conditioning stimulation was applied to the dorsolateral funiculus at thoracic levels, which selectively activates RNm neurons projecting to the lumbar cord. Stimulation at thoracic levels inhibited evoked responses from hindlimb but not forelimb regions of rDAO, suggesting that inhibitory effects of RNm activity are limb specific. Several studies have reported that olivary neurons have reduced sensitivity to peripheral stimulation during movement; it is likely that RNm-mediated inhibition occurring within the olive contributes to this reduction of sensitivity. Inhibition of rDAO responses by descending motor pathways appears to be a salient feature of olivary function.

Inhibition of the Carotid Sinus Reflex by Stimulation of the Inferior Olive

Science ◽  
1966 ◽  
Vol 154 (3749) ◽  
pp. 674-675 ◽  
Author(s):  
O. A. Smith ◽  
M. A. Nathan
Keyword(s):  
Inferior Olive ◽  
Carotid Sinus ◽  
Stimulation Of

Attenuation of activity-induced increases in cerebellar blood flow by lesion of the inferior olive

2003 ◽  
Vol 285 (3) ◽  
pp. H1177-H1182 ◽  
Author(s):  
Yi Zhang ◽  
Colleen Forster ◽  
Teresa A. Milner ◽  
Costantino Iadecola
Keyword(s):  
Blood Flow ◽  
Cerebellar Cortex ◽  
Inferior Olive ◽  
Purkinje Neurons ◽  
Substantial Portion ◽  
Upper Lip ◽  
Flow Probe ◽  
Sensory Afferents ◽  
Laser Doppler Flow ◽  
Stimulation Of

We sought to define the contribution of the climbing fibers (CF), one of the major inputs to Purkinje neurons, to the increase in cerebellar blood flow (BFcrb) produced by activation of the cerebellar cortex. The neurotoxin 3-acetylpyridine was used to lesion the inferior olive, the site from which the CF originate. Crus II, an area of the cerebellar cortex that receives sensory afferents from the perioral region, was activated by low-intensity stimulation of the upper lip (5–25 V and 4–16 Hz) in sham-lesioned and lesioned mice. BFcrb was recorded in crus II using a laser-Doppler flow probe. The increase in BFcrb produced by harmaline, an alkaloid that activates the CF, was abolished in lesioned mice ( P > 0.05 vs. BFcrb before harmaline, n = 6), attesting to the effectiveness of the lesion. In sham-lesioned animals, upper lip stimulation increased BFcrb in crus II by 25 ± 2% (25 V and 10 Hz, n = 6). The rise in BFcrb was attenuated by 63 ± 7% (25 V and 10 Hz) in lesioned mice ( P < 0.05, n = 6). In contrast, the increase in BFcrb produced by hypercapnia was not affected ( P > 0.05). These data suggest that CF are responsible for a substantial portion of the increase in BFcrb produced by crus II activation. Thus the hemodynamic response evoked by functional activation of the cerebellar cortex reflects, in large part, CF activity.

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