Further characterization of acute myelogenous leukemia with t(8; 21) chromosome translocation

1982 ◽  
Vol 6 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Masaharu Sakurai ◽  
Yasuhiko Kaneko ◽  
Rokuo Abe
Keyword(s):  
Acute Myelogenous Leukemia ◽  
Chromosome Translocation ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

scholarly journals Preclinical Characterization of AMG 330, a CD3/CD33-Bispecific T-Cell–Engaging Antibody with Potential for Treatment of Acute Myelogenous Leukemia

2014 ◽  
Vol 13 (6) ◽  
pp. 1549-1557 ◽  
Author(s):  
Matthias Friedrich ◽  
Anja Henn ◽  
Tobias Raum ◽  
Monika Bajtus ◽  
Katja Matthes ◽  
...  
Keyword(s):  
T Cell ◽  
Acute Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Acute Myelogenous

NUP98 Is Fused to PMX1 Homeobox Gene in Human Acute Myelogenous Leukemia With Chromosome Translocation t(1;11)(q23;p15)

Blood ◽  
1999 ◽  
Vol 94 (2) ◽  
pp. 741-747 ◽  
Author(s):  
Takuro Nakamura ◽  
Yukari Yamazaki ◽  
Yoshiaki Hatano ◽  
Ikuo Miura
Keyword(s):  
Transcriptional Activation ◽  
Acute Myelogenous Leukemia ◽  
Constitutive Expression ◽  
Homeobox Gene ◽  
Fusion Transcript ◽  
Chromosome Translocation ◽  
Myelogenous Leukemia ◽  
Homeodomain Protein ◽  
Transcriptional Activation Domain ◽  
Acute Myelogenous

Abstract The nucleoporin gene NUP98 was found fused to theHOXA9, HOXD13, or DDX10 genes in human acute myelogenous leukemia (AML) with chromosome translocations t(7;11)(p15;p15), t(2;11)(q35;p15), or inv(11)(p15;q22), respectively. We report here the fusion between the NUP98 gene and another homeobox gene PMX1 in a case of human AML with a t(1;11)(q23;p15) translocation. The chimeric NUP98-PMX1transcript was detected; however, there was no reciprocalPMX1-NUP98 fusion transcript. Like the NUP98-HOXA9fusion, NUP98 and PMX1 were fused in frame and the N-terminal GLFG-rich docking region of the NUP98 and the PMX1 homeodomain were conserved in the NUP98-PMX1 fusion, suggesting that PMX1 homeodomain expression is upregulated and that the fusion protein may act as an oncogenic transcription factor. The fusion to NUP98 results in the addition of the strong transcriptional activation domain located in the N-terminal region of NUP98 to PMX1. These findings suggest that constitutive expression and alteration of the transcriptional activity of the PMX1 homeodomain protein may be critical for myeloid leukemogenesis.

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