Introductions of opossum shrimp (Mysis relicta) and kokanee salmon (Oncorhynchus nerka) are common management tools for improvement of local sport fisheries. This paper summarizes published information from varied sources and presents supplemental data on the impact of these introductions on the Lake Tahoe zooplankton and fish communities. Concomitant with peak spawning runs of kokanee and the establishment and high densities of Mysis was the disappearance of the three pelagic cladoceran species in the lake. Population dynamics analysis of the cladoceran populations indicate that their elimination was due to increasing death rates (related to Mysis and kokanee predation) and decreasing birth rates (possibly related to cultural eutrophication). Changes have also been observed in the fish populations. Lake trout have altered their food habits to include large quantities of Mysis, but this has been done to the exclusion of other prey types. Thus, improvement in lake trout condition has been indicated only in years when Mysis is abundant. Recent evidence of a sustained decline in the mysid population suggests that unless lake trout shift back to more traditional food sources, their condition could deteriorate to below pre-mysid levels. Finally, mean weight and abundance of kokanee spawners have declined since the cladoceran disappearance, suggesting a negative impact on the whole population which fed heavily on cladocerans. Key words: opossum shrimp, kokanee salmon, population dynamics, cladoceran decline, introductions, subalpine lake