Studies on age related changes in cytochrome P-450, cytochrome b-5 and mixed function oxidase activity in mouse liver microsomes, in relation to their phospholipid composition

1982 ◽  
Vol 1 (1) ◽  
pp. 55-74 ◽  
Author(s):  
D.M. Hawcroft ◽  
T.W.G. Jones ◽  
P.A. Martin
Keyword(s):  
Cytochrome B ◽  
Oxidase Activity ◽  
Mouse Liver ◽  
Liver Microsomes ◽  
Phospholipid Composition ◽  
Mixed Function Oxidase ◽  
Age Related ◽  
Cytochrome P 450 ◽  
Age Related Changes ◽  
Mixed Function Oxidase Activity

Effect of storage on microsomal mixed function oxidase activity in mouse liver

1974 ◽  
Vol 23 (17) ◽  
pp. 2391-2394 ◽  
Author(s):  
Charles L. Litterst ◽  
Edward G. Mimnaugh ◽  
Reginald L. Reagan ◽  
Theodore E. Gram
Keyword(s):  
Oxidase Activity ◽  
Mouse Liver ◽  
Mixed Function Oxidase ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

scholarly journals Growth hormone and drug metabolism. Acute effects on microsomal mixed-function oxidase activities in rat liver

1976 ◽  
Vol 154 (2) ◽  
pp. 433-438 ◽  
Author(s):  
J T. Wilson ◽  
T C. Spelsberg
Keyword(s):  
Growth Hormone ◽  
Drug Metabolism ◽  
Rat Liver ◽  
Oxidase Activity ◽  
Male Rats ◽  
Mixed Function Oxidase ◽  
Liver Growth ◽  
Mixed Function Oxidases ◽  
Cytochrome P 450 ◽  
Mixed Function Oxidase Activity

Adult male rats were subjected either to sham operation or to hypophysectomy and adrenalectomy and maintained for a total of 10 days before treatment with growth hormone. Results of the early effects of growth hormone on the activities of the mixed-function oxidases in rat liver over a 96h period after growth-hormone treatment are presented. 2. Hypophysectomy and adrenalectomy result in decreased body and liver weight and decreased drug metabolism (mixed-function oxidases). Concentrations of electron-transport-system components are also decreased. 3. In the hypophysectomized/adrenalectomized rats, growth hormone decreases the activities of the liver mixed-function oxidases and the cytochrome P-450 and cytochrome c reductases, as well as decreasing the concentration of cytochrome P-450 compared with that of control rats. Similar but less dramatic results are obtained with sham-operated rats. 4. It is concluded that whereas growth hormone enhances liver growth, including induction of many enzyme activities, it results in a decrease in mixed-function oxidase activity. Apparently, mixed-function oxidase activity decreases in liver when growth (mitogenesis) increases.

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