Reduction of lung diffusion for carbon monoxide in patients with lung carcinoma

Background: To determine the respiratory outcomes in patients following COVID-19-related hospitalization.Methods: Systematic review and meta-analysis of the literature.Results: Forced vital capacity (FVC, % of predicted): 0–3 months post discharge: 96.1, 95% CI [82.1–110.0]; 3–6 months post discharge: 99.9, 95% CI [84.8, 115.0]; >6 months post discharge: 97.4, 95% CI [76.8–118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0–3 months post discharge: 83.9, 95% CI [68.9–98.9]; 3–6 months post discharge: 91.2, 95% CI [74.8–107.7]; >6 months post discharge: 97.3, 95% CI [76.7–117.9]. Percentage of patients with FVC less than 80% of predicted: 0–3 months post discharge: 10%, 95% CI [6–14%]; 3–6 months post discharge: 10%, 95% CI [2–18%]; >6 months post discharge: 13%, 95% CI [8–18%]. Percentage of patients with DLCO less than 80% of predicted: 0–3 months post discharge: 48%, 95% CI [41–56%]; 3–6 months post discharge: 33%, 95% CI [23–44%]; >6 months post discharge: 43%, 95% CI [22–65%].Conclusion: The meta-analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalization. Routine respiratory follow-up is thus strongly recommended.

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Could lung diffusion level for carbon monoxide be predicted in young elite athletes?

10.1183/1393003.congress-2017.pa3005 ◽

2017 ◽

Author(s):

Biljana Lazovic ◽

Mirjana Zlatkovic-Svenda ◽

Jelena Grbovic ◽

Vesna Djuric ◽

Branislava Milenkovic ◽

...

Keyword(s):

Carbon Monoxide ◽

Elite Athletes ◽

Lung Diffusion

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Studies on the Lung Diffusion Coefficient for Carbon Monoxide in Normal Human Subjects by means of C14O.

Acta Physiologica Scandinavica ◽

10.1111/j.1748-1716.1954.tb01160.x ◽

1954 ◽

Vol 32 (2-3) ◽

pp. 106-123 ◽

Cited By ~ 45

Author(s):

POUL KRUHØFFER

Keyword(s):

Carbon Monoxide ◽

Diffusion Coefficient ◽

Human Subjects ◽

Lung Diffusion ◽

Normal Human

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Carbon monoxide lung diffusion capacity improves risk stratification in patients without airflow limitation: evidence for systematic measurement before lung resection

European Journal of Cardio-Thoracic Surgery ◽

10.1016/j.ejcts.2006.01.014 ◽

2006 ◽

Vol 29 (4) ◽

pp. 567-570 ◽

Cited By ~ 64

Author(s):

Alessandro Brunelli ◽

Majed Al Refai ◽

Michele Salati ◽

Armando Sabbatini ◽

Nicholas J. Morgan-Hughes ◽

...

Keyword(s):

Carbon Monoxide ◽

Risk Stratification ◽

Lung Resection ◽

Airflow Limitation ◽

Systematic Measurement ◽

Lung Diffusion ◽

Diffusion Capacity

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The COPD Assessment Test as a Prognostic Marker in Interstitial Lung Disease

Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine ◽

10.4137/ccrpm.s40792 ◽

2016 ◽

Vol 10 ◽

pp. CCRPM.S40792 ◽

Cited By ~ 5

Author(s):

Fujiko Someya ◽

Takao Nakagawa ◽

Naoki Mugii

Keyword(s):

Carbon Monoxide ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Rank Test ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Lung Diffusion ◽

Diffusion Capacity ◽

Copd Assessment Test ◽

One Year

The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT), which was developed to measure the health status of patients with COPD, was applied to patients with interstitial lung disease, aiming to examine the CAT as a predictor of outcome. Over a follow-up period of more than one year, 101 consecutive patients with interstitial lung disease were evaluated by the CAT. The CAT scores of 40 in total were categorized into four subsets according to the severity. Patients with higher (more severe) scores exhibited lower forced vital capacity and lung diffusion capacity for carbon monoxide. The survival rate was significantly lower in patients with higher scores (log-rank test, P = 0.0002), and the hazard ratios for death of the higher scores and lower lung diffusion capacity for carbon monoxide were independently significant. These findings suggest that CAT can indicate the risk of mortality in patients with interstitial lung disease.

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