Rapid steady-state analysis of blood-brain transfer of l-Trp in rat, with special reference to the plasma protein binding

1993 ◽  
Vol 23 (4) ◽  
pp. 351-359 ◽  
Author(s):  
A. Takada ◽  
M. Grdiša ◽  
M. Diksic ◽  
A. Gjedde ◽  
Y.L. Yamamoto
Keyword(s):  
Steady State ◽  
Protein Binding ◽  
Special Reference ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Steady State Analysis ◽  
Blood Brain ◽  
State Analysis

Effect of erythrocytes and plasma protein binding on the transport of progabide and SL 75102 through the rat blood-brain barrier

1987 ◽  
Vol 36 (16) ◽  
pp. 2641-2645 ◽  
Author(s):  
C. Hamberger ◽  
S. Urien ◽  
D. Essassi ◽  
B. Grimaldi ◽  
J. Barre ◽  
...  
Keyword(s):  
Protein Binding ◽  
Blood Brain Barrier ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Brain Barrier ◽  
Rat Blood ◽  
Blood Brain

Renal and nonrenal clearances of ceftriaxone at the steady-state and its relation to plasma protein binding

1995 ◽  
Vol 3 (3) ◽  
pp. 133-138 ◽  
Author(s):  
José-Esteban Peris ◽  
María Pascual-Arce ◽  
Luis Granero ◽  
Jesús Chesa-Jiménez ◽  
Mercedes Almela
Keyword(s):  
Steady State ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein

Plasma protein binding limits the blood brain barrier permeation of the pyrethroid insecticide, deltamethrin

2016 ◽  
Vol 250-251 ◽  
pp. 21-28 ◽  
Author(s):  
Manoj Amaraneni ◽  
Anshika Sharma ◽  
Jing Pang ◽  
Srinivasa Muralidhara ◽  
Brian S. Cummings ◽  
...  
Keyword(s):  
Protein Binding ◽  
Blood Brain Barrier ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Pyrethroid Insecticide ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

2010 ◽  
Vol 23 (4) ◽  
pp. 858-883 ◽  
Author(s):  
Roland Nau ◽  
Fritz Sörgel ◽  
Helmut Eiffert
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Molecular Size ◽  
Transport Systems ◽  
Cns Infections ◽  
Blood Brain

SUMMARY The entry of anti-infectives into the central nervous system (CNS) depends on the compartment studied, molecular size, electric charge, lipophilicity, plasma protein binding, affinity to active transport systems at the blood-brain/blood-cerebrospinal fluid (CSF) barrier, and host factors such as meningeal inflammation and CSF flow. Since concentrations in microdialysates and abscesses are not frequently available for humans, this review focuses on drug CSF concentrations. The ideal compound to treat CNS infections is of small molecular size, is moderately lipophilic, has a low level of plasma protein binding, has a volume of distribution of around 1 liter/kg, and is not a strong ligand of an efflux pump at the blood-brain or blood-CSF barrier. When several equally active compounds are available, a drug which comes close to these physicochemical and pharmacokinetic properties should be preferred. Several anti-infectives (e.g., isoniazid, pyrazinamide, linezolid, metronidazole, fluconazole, and some fluoroquinolones) reach a CSF-to-serum ratio of the areas under the curves close to 1.0 and, therefore, are extremely valuable for the treatment of CNS infections. In many cases, however, pharmacokinetics have to be balanced against in vitro activity. Direct injection of drugs, which do not readily penetrate into the CNS, into the ventricular or lumbar CSF is indicated when other effective therapeutic options are unavailable.

Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood–brain barrier maturation

2017 ◽  
Vol 62 ◽  
pp. 24-29 ◽  
Author(s):  
Manoj Amaraneni ◽  
Jing Pang ◽  
Tanzir B. Mortuza ◽  
Srinivasa Muralidhara ◽  
Brian S. Cummings ◽  
...  
Keyword(s):  
Protein Binding ◽  
Blood Brain Barrier ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Brain Barrier ◽  
Brain Uptake ◽  
Blood Brain
Sign in / Sign up

Export Citation Format

Share Document