ROLE OF METALLOTHIONEIN AND OTHER ANTIOXIDANTS IN SCAVENGING SUPEROXIDE RADICALS AND THEIR POSSIBLE ROLE IN NEUROPROTECTION

1996 ◽  
Vol 29 (2) ◽  
pp. 145-152 ◽  
Author(s):  
SABER HUSSAIN ◽  
WILLIAM SLIKKER Jr ◽  
SYED F ALI
Keyword(s):  
1999 ◽  
Vol 69 (10) ◽  
pp. 769-775 ◽  
Author(s):  
K. Fukatsu ◽  
S. Kokot ◽  
D.P. Schweinsberg

1984 ◽  
Vol 107 (3) ◽  
pp. 390-394 ◽  
Author(s):  
kjell Asplund ◽  
Kjell Grankvist ◽  
Stefan Marklund ◽  
Inge-Bert Täljedal

Abstract. To test the possible role of superoxide radicals in the diabetogenic action of streptozotocin, blood glucose levels were measured in mice after a single high-dose (150 mg/kg body weight) or multiple low-dose (40 mg/kg for 5 days) injections of streptozotocin. Pre-treatment 6 h before streptozotocin with 250–300 mg/kg superoxide dismutase coupled to polyethylene glycol reduced the hyperglycaemic response in mice injected with a single dose of streptozotocin. The blood glucose levels after multiple low doses of streptozotocin were not affected by superoxide dismutase-polvethvlene glycol. Enzymatically inactive superoxide dismutase did not affect the development of hyperglycaemia. The results suggest that superoxide radicals may play a role in the diabetogenic action of streptozotocin injected as a high-dose single bolus.


Chemosphere ◽  
2020 ◽  
Vol 244 ◽  
pp. 125490 ◽  
Author(s):  
Shaohua Wu ◽  
Haiyang Liu ◽  
Yan Lin ◽  
Chunping Yang ◽  
Wei Lou ◽  
...  

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