The effect of intravenous administration of fat emulsion on the flow rate and composition of thoracic duct lymph in the dog

1989 ◽  
Vol 8 (2) ◽  
pp. 75-78 ◽  
Author(s):  
M Andel
Keyword(s):  
Flow Rate ◽  
Intravenous Administration ◽  
Thoracic Duct ◽  
Thoracic Duct Lymph ◽  
Fat Emulsion ◽  
Duct Lymph

Thoracic duct lymph flow and its measurement in chronically catheterized sheep fetus

1989 ◽  
Vol 256 (1) ◽  
pp. H16-H20 ◽  
Author(s):  
R. A. Brace
Keyword(s):  
Flow Rate ◽  
Thoracic Duct ◽  
Lymphatic Vessels ◽  
Lymph Flow ◽  
Thoracic Duct Lymph ◽  
Computer Technique ◽  
Venous Circulation ◽  
Duct Lymph ◽  
Unit Body Weight ◽  
Sheep Fetus

A method was developed for chronic catheterization of the left thoracic lymph duct at the base of the neck in the sheep fetus, which did not disrupt the other major lymphatic vessels that join the venous circulation at the same location. The lymphatic catheter was connected to a catheter in a jugular vein when lymph flow was not being recorded, so that the lymph continuously returned to the fetal circulation. Special consideration of catheter size to minimize flow resistance and treatment to prevent clotting were required. Individual animals were maintained up to 17 days with lymph flow continuing. In 13 fetuses averaging 128 days gestation (term = 147 days) at the time of catheterization, lymph flow rate was measured for 1 h each day for the first 7 postsurgical days with an on-line computer technique that continuously calculated lymph flow rate. Lymph flow averaged 0.64 +/- 0.17 (SD) ml/min in fetuses weighing 2.3-4 kg and tended to undergo a nonsignificant increase with time. Lymph and plasma protein concentrations did not change with time. In individual fetuses, large spontaneous variations in lymph flow rate occurred over periods of several seconds to a few minutes. Analysis showed that these variations in flow rate were not associated with fetal breathing movements. Thus the present study describes a technique for studying the dynamics of lymph flow in the unanesthetized sheep fetus in utero over a time period limited primarily by the length of gestation. In addition, it appears that thoracic duct lymph flow rate in the fetus per unit body weight averages three to four times that in the adult.

Effect of Somatostatin on the Flow Rate and Triglyceride Levels of Thoracic Duct Lymph In Normal and Vagotomized Dogs

Diabetes ◽  
1981 ◽  
Vol 30 (5) ◽  
pp. 440-445 ◽  
Author(s):  
H. Nakabayashi ◽  
H. Sagara ◽  
N. Usukura ◽  
K. Yoshimitsu ◽  
T. Imamura ◽  
...  
Keyword(s):  
Flow Rate ◽  
Thoracic Duct ◽  
Thoracic Duct Lymph ◽  
Duct Lymph

scholarly journals Cholesterol feeding alters the metabolism of thoracic-duct lymph lipoprotein cholesterol in rabbits but not in rats

1973 ◽  
Vol 136 (1) ◽  
pp. 109-113 ◽  
Author(s):  
T. G. Redgrave
Keyword(s):  
Cholesteryl Ester ◽  
Intravenous Administration ◽  
Thoracic Duct ◽  
Dietary Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Thoracic Duct Lymph ◽  
Cholesterol Feeding ◽  
Duct Lymph ◽  
Glyceryl Trioleate ◽  
Hydrolysis Of

1. Labelled thoracic-duct lymph was collected from rats and rabbits after test meals containing [14C]cholesterol and [2-3H]glyceryl trioleate. 2. The metabolism of labelled cholesterol and triglyceride was studied in normally fed and cholesterol-fed rats and rabbits injected with radioactive lymph from the same species. 3. In normally fed animals of both species, 10min after intravenous administration, about 80% of lymph cholesteryl ester but only about 10% of triglyceride was recovered in the liver after clearance from the plasma. This distribution is consistent with participation of ‘remnant’ particles in the metabolism of dietary lymph particles. 4. The metabolism of cleared lymph lipoprotein constituents was unchanged in cholesterol-fed rats, but the recovery of cholesteryl ester in the livers of the cholesterol-fed rabbits was decreased to 30% of the cleared dose. 5. The low recovery in cholesterol-fed rabbits was accounted for mainly by increased hydrolysis of cholesteryl ester. 6. It is proposed that differences between rats and rabbits in metabolism of dietary cholesterol might be partly due to the observed enhancement of hydrolysis of lymph lipoprotein cholesteryl ester in rabbits.

Diuretics, Hepatic and Thoracic Duct Lymph Flows in the Dog

1979 ◽  
Vol 56 (3) ◽  
pp. 211-214
Author(s):  
J. J. Szwed ◽  
D. R. Maxwell
Keyword(s):  
Intravenous Administration ◽  
Thoracic Duct ◽  
Ethacrynic Acid ◽  
Lymph Flow ◽  
Thoracic Duct Lymph ◽  
Diuretic Agent ◽  
Duct Lymph ◽  
Before And After

1. Simultaneous thoracic duct and hepatic lymph flows were measured in 29 mongrel dogs before and after the intravenous administration of mannitol, ethacrynic acid, frusemide and chlorothiazide in separate experiments. 2. Thoracic duct lymph flow increased significantly after each diuretic agent was administered. 3. Hepatic lymph flow increased only after ethacrynic acid and mannitol administration. Frusemide and chlorothiazide did not alter hepatic lymph flow. 4. These data show that increases in thoracic duct lymph flow after ethacrynic acid and mannitol arise partly from the liver, as well as from other organs.

Effects of outflow pressure and vascular volume loading on thoracic duct lymph flow in adult sheep

1990 ◽  
Vol 258 (1) ◽  
pp. R240-R244 ◽  
Author(s):  
R. A. Brace ◽  
G. J. Valenzuela
Keyword(s):  
Flow Rate ◽  
Thoracic Duct ◽  
Venous Pressure ◽  
Ringer Solution ◽  
Lymph Flow ◽  
Thoracic Duct Lymph ◽  
Volume Loading ◽  
Vascular Volume ◽  
Duct Lymph ◽  
Lymph Duct

Studies have shown that lymph flow rate from several tissues depends on the pressure at the outflow end of the lymphatics. The left thoracic lymph duct is the largest lymphatic vessel and it transports a majority of the body's lymph. We varied outflow pressure for the left thoracic lymph duct independent of venous pressure in six unanesthetized, nonpregnant adult ewes with chronic lymphatic and venous catheters. When outflow pressure was negative, the thoracic duct lymph flow rate was independent of outflow pressure and averaged 0.040 +/- 0.004 (SE) ml.min-1.kg body wt-1. Lymph flow began to decrease with increasing outflow pressure only when outflow pressure was significantly greater than venous pressure. Above this breakpoint, lymph flow decreased linearly with outflow pressure and ceased at an outflow pressure of 25.6 +/- 4.2 mmHg. After vascular volume loading with lactated Ringer solution, steady-state thoracic duct lymph flow increased to 351 +/- 54% of control and was independent of outflow pressure when outflow pressure was negative. As outflow pressure was elevated, lymph flow began to decrease at the same breakpoint as before volume loading, and lymph flow ceased at the same outflow pressure as before volume loading. Thus this study shows that there is a plateau where thoracic duct lymph flow rate is independent of outflow pressure. In addition venous pressure under normal or volume-loaded conditions is not an impediment to thoracic duct lymph flow in unanesthetized sheep. Large increases in venous pressure are required to totally block thoracic duct lymph flow.

scholarly journals The Effect of Outflow Pressure upon Thoracic Duct Lymph Flow Rate in Fetal Sheep

1992 ◽  
Vol 32 (5) ◽  
pp. 585-588 ◽  
Author(s):  
Alfred L Gest ◽  
Derek K Bair ◽  
Mary C Vander Straten
Keyword(s):  
Flow Rate ◽  
Thoracic Duct ◽  
Lymph Flow ◽  
Thoracic Duct Lymph ◽  
Fetal Sheep ◽  
Duct Lymph
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