The presence of blood in the stomach lumen increases splanchnic blood flow and portal pressure in portal hypertensive rats VA Medical Center, West Haven and Yale University School of Medicine, New Haven, CT
Blood flow in the celiac and superior mesenteric arteries was measured in nine Macaca monkeys during a standardized hemorrhagic shock procedure. Simultaneous pressures were obtained from the hepatic vein, portal vein, and aorta. Each animal was bled rapidly to an arterial pressure of 40 mm Hg and maintained at this level until 30% of the bled volume had spontaneously reinfused. The remaining blood was then rapidly reinfused and the animal observed until death. The results show a lack of overshoot of venous pressure on reinfusion, grossly pale intestines with some microscopic congestive changes, and a decrease in splanchnic conductance throughout the postinfusion period. Hepatic venous pressure exceeded portal pressure in six of the nine animals during the period of hemorrhage. The results are interpreted as indicative of insignificant splanchnic pooling during hemorrhagic shock in this animal.
Intercellular Debris in the Stratum Corneum of the Human Epidermis**From the Section of Dermatology, Department of Medicine and Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut.