Human corticotropin releasing hormone: Clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls

1988 ◽  
Vol 12 ◽  
pp. S165-S187 ◽  
Author(s):  
Ulrich Von Bardeleben ◽  
Florian Holsboer
Keyword(s):  
Panic Disorder ◽  
Clinical Studies ◽  
Affective Disorders ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Normal Controls

Trouble Panique et Alcoolisme: Influence de la Comorbidité

1993 ◽  
Vol 38 (7) ◽  
pp. 485-493 ◽  
Author(s):  
J.M. Chignon ◽  
J.P. Lépine
Keyword(s):  
Alcohol Abuse ◽  
Panic Disorder ◽  
Clinical Studies ◽  
Affective Disorders ◽  
Related Disorder ◽  
Addictive Disorders ◽  
Lifetime History ◽  
High Prevalence ◽  
History Of ◽  
History Of Depression

Both epidemiological and clinical studies have demonstrated a high prevalence of panic disorder among alcoholic patients. In contrast, little attention has been given to studying alcohol abuse and/or dependence in patients suffering from panic disorder. One hundred and fifty-five consecutive referrals for treatment for panic disorder were interviewed using a modified version of the Schedule for Affective Disorders and Schizophrenia—Lifetime Version, modified for the study of anxiety disorders. Thirty-two patients (20.7%) had a lifetime history of alcohol abuse and/or dependence. Although the lifetime comorbidity rate of either agoraphobia and/or social phobia seems without any influence on the risk of alcohol-related disorder, alcoholic patients suffering from panic disorder appear to be more likely to have a history of depression and other addictive disorders. The majority of patients with primary alcoholism were male, and those who became alcoholics after they developed panic disorder were more likely to be female. The comparison between patients with primary and secondary alcoholism did not indicate any difference in the comorbidity rate with other psychiatric disorders nor the severity of panic disorder.

Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II

1995 ◽  
Vol 38 (12) ◽  
pp. 803-807 ◽  
Author(s):  
Claas-H. Lammers ◽  
Diego Garcia-Borreguero ◽  
Jürgen Schmider ◽  
Ulrike Gotthardt ◽  
Michael Dettling ◽  
...  
Keyword(s):  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Normal Controls

Basic and Clinical Studies with Corticotropin-Releasing Hormone

1988 ◽  
Vol 11 (2) ◽  
pp. 327-334 ◽  
Author(s):  
Philip W. Gold ◽  
Teresa A. Pigott ◽  
Mitchel A. Kling ◽  
Konstantine Kalogeras ◽  
George P. Chrousos
Keyword(s):  
Clinical Studies ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Enhanced corticotropin response to corticotropin-releasing hormone as a predictor of mania in euthymic bipolar patients

1999 ◽  
Vol 29 (4) ◽  
pp. 971-978 ◽  
Author(s):  
E. VIETA ◽  
M. J. MARTÍNEZ-DE-OSABA ◽  
F. COLOM ◽  
A. MARTÍNEZ-ARÁN ◽  
A. BENABARRE ◽  
...  
Keyword(s):  
Challenge Test ◽  
Cortisol Response ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Free Cortisol ◽  
Before And After ◽  
Acth Concentration ◽  
Bipolar Patients ◽  
Normal Controls

Background. Dysregulation of corticotropin (ACTH) and cortisol response after corticotropin-releasing hormone (CRH) stimulation has been reported in bipolar patients. Most findings involve the pathophysiology of the depressive phase of the illness and its prediction. However, the possible predictive value of the CRH challenge test with respect to manic episodes remains unknown.Methods. The ACTH and free cortisol response to the injection of 100 μg of synthetic human CRH and plasma cortisol-binding globulin levels were measured in 42 lithium-treated patients suffering from Research Diagnostic Criteria bipolar I disorder in remission, and 21 age- and sex-matched normal controls. A 1-year follow-up was conducted to assess any possible relationship between outcome and the hormonal response.Results. Bipolar patients showed higher baseline and peak ACTH concentrations than control subjects. A higher area under ACTH concentration curve after CRH stimulation predicted manic/hypomanic relapse within 6 months by multiple regression analysis.Conclusion. Bipolar patients in remission show mild abnormalities in ACTH levels before and after CRH stimulation. CRH challenge may be a potentially good predictor of manic or hypomanic relapse in remitted bipolar patients.

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