Thyroid hormone regulates expression of the thyrotropin β-subunit gene from both transcription start sites in the mouse and rat

1990 ◽  
Vol 71 (3) ◽  
pp. 185-193
Author(s):  
J.A. Gurr ◽  
M.M. Januszeski ◽  
I.M. Tidikis ◽  
J.J. Norcross ◽  
I.A. Kourides
Keyword(s):  
Thyroid Hormone ◽  
Β Subunit ◽  
Subunit Gene ◽  
Transcription Start ◽  
Transcription Start Sites

Genomic organization of the 5′ end of human β-ENaC and preliminary characterization of its promoter

2002 ◽  
Vol 282 (5) ◽  
pp. F898-F909 ◽  
Author(s):  
Christie P. Thomas ◽  
Randy W. Loftus ◽  
Kang Z. Liu ◽  
Omar A. Itani
Keyword(s):  
Genomic Organization ◽  
Human Kidney ◽  
Β Subunit ◽  
Transcription Start ◽  
Transcription Start Sites ◽  
Nuclear Extracts ◽  
Flanking Region ◽  
Rapid Amplification ◽  
Flanking Regions

The mRNA for the β-subunit of the epithelial Na+ channel (β-ENaC) is regulated developmentally and, in some tissues, in response to corticosteroids. To understand the mechanisms of transcriptional regulation of the human β-ENaC gene, we characterized the 5′ end of the gene and its 5′-flanking regions. Adaptor-ligated human kidney and lung cDNA were amplified by 5′ rapid amplification of cDNA ends, and transcription start sites of two 5′ variant transcripts were determined by nuclease protection or primer extension assays. Cosmid clones that contain the 5′ end of the gene were isolated, and analysis of these clones indicated that alternate first exons ∼1.5 kb apart and ∼ 45 kb upstream of a common second exon formed the basis of these transcripts. Genomic fragments that included the proximal 5′-flanking region of either transcript were able to direct expression of a reporter gene in lung epithelia and to bind Sp1 in nuclear extracts, confirming the presence of separate promoters that regulate β-ENaC expression.

Thyroid Hormone Regulation of Thyrotropin α- and β-Subunit Gene Transcription

DNA ◽  
1985 ◽  
Vol 4 (4) ◽  
pp. 301-307 ◽  
Author(s):  
JAMES A. GURR ◽  
IONE A. KOURIDES
Keyword(s):  
Thyroid Hormone ◽  
Gene Transcription ◽  
Hormone Regulation ◽  
Β Subunit ◽  
Subunit Gene

The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene

2018 ◽  
pp. 97-127 ◽  
Author(s):  
Shigekazu Sasaki ◽  
Akio Matsushita ◽  
Go Kuroda ◽  
Hiroko M. Nakamura ◽  
Yutaka Oki ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Thyroid Hormone ◽  
Β Subunit ◽  
Subunit Gene

The proto-oncogenes c-fos and c-jun modulate thyroid hormone inhibition of human thyrotropin β subunit gene expression in opposite directions

1992 ◽  
Vol 189 (2) ◽  
pp. 1050-1056 ◽  
Author(s):  
Donald L. Bodenner ◽  
John H. McClaskey ◽  
Myung K. Kim ◽  
A. James Mixson ◽  
Bruce D. Weintraub
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Β Subunit ◽  
Subunit Gene

scholarly journals Thyroid Hormone Inhibition of Human Thyrotropin β-Subunit Gene Expression is Mediated by a Cis-acting Element Located in the First Exon

1989 ◽  
Vol 264 (25) ◽  
pp. 14601-14604 ◽  
Author(s):  
F E Wondisford ◽  
E A Farr ◽  
S Radovick ◽  
H J Steinfelder ◽  
J M Moates ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Β Subunit ◽  
Subunit Gene ◽  
Cis Acting

scholarly journals Thyroid Hormone Regulates the Mouse Thyrotropin β-Subunit Gene Promoter in Transfected Primary Thyrotropes

1989 ◽  
Vol 264 (25) ◽  
pp. 14840-14847 ◽  
Author(s):  
W M Wood ◽  
M Y Kao ◽  
D F Gordon ◽  
E C Ridgway
Keyword(s):  
Thyroid Hormone ◽  
Gene Promoter ◽  
Β Subunit ◽  
Subunit Gene

The chorionic gonadotropin β-subunit gene is controlled by Pitx1 and Egr1

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
A Henke ◽  
M Simoni ◽  
E Nieschlag ◽  
J Gromoll
Keyword(s):  
Chorionic Gonadotropin ◽  
Β Subunit ◽  
Subunit Gene

Cloning and Analyzing of G-protein β-Subunit Gene in Rhizoctonia solani Causing Soybean Sharp Eyespot

2009 ◽  
Vol 35 (2) ◽  
pp. 370-374
Author(s):  
Bing-Tian MA ◽  
Guang-Lin QU ◽  
Wen-Juan HUANG ◽  
Yu-Fan LIN ◽  
Shi-Gui LI
Keyword(s):  
Rhizoctonia Solani ◽  
G Protein ◽  
Β Subunit ◽  
Subunit Gene ◽  
Sharp Eyespot
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