DNA single-strand breaks by nitropyrenes and related compounds in Chinese hamster V79 cells

1984 ◽  
Vol 24 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Kazuki Saito ◽  
Shiro Mita ◽  
Tetsuya Kamataki ◽  
Ryuichi Kato
Keyword(s):  
Chinese Hamster ◽  
Single Strand ◽  
V79 Cells ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Chinese Hamster V79 Cells ◽  
Related Compounds

Induction of DNA double-strand breaks in Chinese hamster V79 cells by 2-chlorodeoxyadenosine

1989 ◽  
Vol 71 (2-3) ◽  
pp. 167-175 ◽  
Author(s):  
Kiyoshi Tanabe ◽  
Wakako Hiraoka ◽  
Mikinori Kuwabara ◽  
Fumiaki Sato ◽  
Akira Matsuda ◽  
...  
Keyword(s):  
Chinese Hamster ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
V79 Cells ◽  
Strand Breaks ◽  
Chinese Hamster V79 Cells

Niltrogen dioxide induces DNA single-strand breaks in cultured Chinese hamster cells

1990 ◽  
Vol 11 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Sylvia Görsdorf ◽  
Klaus E. Appel ◽  
Cindy Engeholm ◽  
Günter Obe
Keyword(s):  
Chinese Hamster ◽  
Single Strand ◽  
Strand Breaks ◽  
Chinese Hamster Cells ◽  
Single Strand Breaks

Toxicity, Clastogenicity and Genotoxicity of Theophylline and Pentoxifylline in Mammalian Cells Cultured In Vitro

1995 ◽  
Vol 23 (4) ◽  
pp. 504-512
Author(s):  
Darina Slameňová ◽  
Ivan Chalupa ◽  
Alena Gábelová ◽  
Eva Bozsakyová ◽  
Eva Horváthová ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Term Treatment ◽  
Single Strand ◽  
Toxic Effects ◽  
Short Term ◽  
Short Term Treatment ◽  
V79 Cells ◽  
Strand Breaks ◽  
Single Strand Breaks

— As part of a developmental study on theophylline and pentoxifylline, these drugs were tested for possible cytotoxic, mutagenic and clastogenic effects on V79 hamster cells and human lymphocytes cultured in vitro. After the short-term treatment of V79 cells with theophylline and pentoxifylline, the cells were relatively resistant to the toxic effects of these methylxanthines. Generally, only high concentrations of theophylline or pentoxifylline had toxic effects on exposed V79 cells. Short-term treatment of V79 cells with theophylline or pentoxifylline did not induce 6-thioguanine resistant mutations in either the presence or absence of S9 fractions. However, in the absence of an S9 fraction, elevated levels of single-strand breaks in DNA were induced. Both methylxanthines caused clastogenic effects in human lymphocytes and hamster V79 cells after long-term exposure. We suggest that theophylline and pentoxifylline are clastogenic but not genotoxic, and that the molecular mechanism for the induction of single-strand breaks in DNA and the induction of chromosomal aberrations in cells treated with theophylline and pentoxifylline is not the induction of lesions in the DNA but the inhibition of DNA chain elongation.

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