The Ultra-fast Repair of Single-strand Breaks in DNA of γ-irradiated Chinese Hamster Cells

1976 ◽  
Vol 30 (6) ◽  
pp. 577-580 ◽  
Author(s):  
G.A. Leontjeva ◽  
Yu.A. Mantzighin ◽  
A.I. Gaziev
Keyword(s):  
Chinese Hamster ◽  
Single Strand ◽  
Strand Breaks ◽  
Chinese Hamster Cells ◽  
Single Strand Breaks ◽  
Fast Repair

Niltrogen dioxide induces DNA single-strand breaks in cultured Chinese hamster cells

1990 ◽  
Vol 11 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Sylvia Görsdorf ◽  
Klaus E. Appel ◽  
Cindy Engeholm ◽  
Günter Obe
Keyword(s):  
Chinese Hamster ◽  
Single Strand ◽  
Strand Breaks ◽  
Chinese Hamster Cells ◽  
Single Strand Breaks

scholarly journals INDUCTION OF THIOGUANINE- AND OUABAIN-RESISTANT MUTANTS AND SINGLE-STRAND BREAKS IN THE DNA OF CHINESE HAMSTER OVARY CELLS BY 3H-THYMIDINE

Genetics ◽  
1977 ◽  
Vol 87 (1) ◽  
pp. 129-138
Author(s):  
James E Cleaver
Keyword(s):  
Ultraviolet Light ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Single Strand ◽  
X Rays ◽  
Ovary Cells ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Ultraviolet Light Irradiation ◽  
Resistant Mutants

ABSTRACT Cultured Chinese hamster cells were labeled with 6-3H-thymidine or 5-methyl-3H-thymidine and allowed to accumulate damage from 3H decays for various periods of time while frozen. The frequencies of cells resistant to 6-thioguanine or ouabain and the amount of DNA damage (i.e., number of single-strand breaks) were determined and compared with the mutation frequencies resulting from X and ultraviolet light irradiation. Whereas 3H decays and X rays made only 6-thioguanine-resistant mutants, ultraviolet light made both 6-thioguanine- and ouabain-resistant mutants. 3H decays originating at the 6 position were two to three times as effective as decays at the 5-methyl position in making drug-resistant mutants, but decays at both sites were equally effective in making single-strand breaks. Mutants and strand breaks produced by beta irradiation of the nucleus probably are the same irrespective of the site of the decay in thymine; these results indicate that the local transmutation effects of 3H decay produce more mutations when they occur at the 6 position than at the 5-methyl position.

Effect of dimethylthiourea on chromium (VI)-induced DNA single-strand breaks in Chinese hamster V-79 cells

1995 ◽  
Vol 346 (4) ◽  
pp. 247-253 ◽  
Author(s):  
Shunji Ueno ◽  
Masayasu Sugiyama ◽  
Nobuyuki Susa ◽  
Yoshinori Furukawa
Keyword(s):  
Chinese Hamster ◽  
Single Strand ◽  
Strand Breaks ◽  
Chromium Vi ◽  
Single Strand Breaks
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