Excitation of neurones in a restricted portion of the midbrain periaqueductal grey elicits both behavioural and cardiovascular components of the defence reaction in the unanaesthetised decerebrate cat

1987 ◽  
Vol 81 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Pascal Carrive ◽  
Roger A.L. Dampney ◽  
Richard Bandler
Emotions ◽  
2015 ◽  
pp. 405-416
Author(s):  
Richard Bandler ◽  
Alan McDougall ◽  
Roger Dampney

The analgesic effects evoked by stimulating midbrain sites are well known but electrical stimulation in the periaqueductal grey matter (PAG) can also produce aggressive or defensive behaviour which is accompanied by a characteristic pattern of autonomic changes termed the ‘defence reaction’ (Abrahams et al. 1960) or ‘visceral alerting’ (Hilton et al. 1983).


2020 ◽  
Vol 13 (12) ◽  
pp. e238545
Author(s):  
Papa Dasari ◽  
Smitha Priyadarshini

A teenage primigravida at 13 weeks of gestation presented with hyperemesis gravidarum of 45 days and a history of giddiness and inability to walk due to involuntary movements of limbs and eyes since 2 days. She was treated with intravenous fluids, thiamine and antiemetics. MRI brain showed hyperintensities in bilateral dorsomedial thalami, periaqueductal grey matter in T2-weighted and FLAIR images. A diagnosis of Wernicke encephalopathy was made and she was managed in intensive care unit and received injection thiamine as per the guidelines and her weakness and ataxia improved over 3 weeks and she was discharged at 17 weeks of pregnancy in good state of health.


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