cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors

1994 ◽  
Vol 169 (1-2) ◽  
pp. 85-89 ◽  
Author(s):  
Jeffrey K. Harrison ◽  
Cynthia M. Barber ◽  
Kevin R. Lynch
Keyword(s):  
Spinal Cord ◽  
G Protein ◽  
Cdna Cloning ◽  
Chemokine Receptors ◽  
Rat Spinal Cord ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

cDNA cloning of a putative G protein-coupled receptor from brain

1995 ◽  
Vol 1261 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Shingo Hata ◽  
Yoshikazu Emi ◽  
Takashi Iyanagi ◽  
Takashi Osumi
Keyword(s):  
G Protein ◽  
Cdna Cloning ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions

2012 ◽  
Vol 189 (6) ◽  
pp. 2824-2832 ◽  
Author(s):  
Sandeep K. Raghuwanshi ◽  
Yingjun Su ◽  
Vandana Singh ◽  
Katherine Haynes ◽  
Ann Richmond ◽  
...  
Keyword(s):  
G Protein ◽  
Chemokine Receptors ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat

2013 ◽  
Vol 44 (3) ◽  
pp. 259-270 ◽  
Author(s):  
Binbin Sun ◽  
Yilu Gao ◽  
Dong Lou ◽  
Xiujie Wu ◽  
Haixiang Wei ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
G Protein ◽  
Acute Spinal Cord Injury ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Adult Rat ◽  
Cord Injury ◽  
G Protein Coupled

scholarly journals Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

1999 ◽  
Vol 190 (9) ◽  
pp. 1241-1256 ◽  
Author(s):  
Brian A. Zabel ◽  
William W. Agace ◽  
James J. Campbell ◽  
Heidi M. Heath ◽  
David Parent ◽  
...  
Keyword(s):  
Small Intestine ◽  
T Lymphocytes ◽  
G Protein ◽  
Chemokine Receptor ◽  
Chemokine Receptors ◽  
Intraepithelial Lymphocytes ◽  
Mucosal Immune Response ◽  
G Protein Coupled Receptor ◽  
Cc Chemokine ◽  
G Protein Coupled

TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein–coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti–GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on a subset of memory α4β7high intestinal trafficking CD4 and CD8 lymphocytes. In addition, all intestinal lamina propria and intraepithelial lymphocytes express GPR-9-6. In contrast, GPR-9-6 is not displayed on cutaneous lymphocyte antigen–positive (CLA+) memory CD4 and CD8 lymphocytes, which traffic to skin inflammatory sites, or on other systemic α4β7−CLA− memory CD4/CD8 lymphocytes. The majority of thymocytes also express GPR-9-6, but natural killer cells, monocytes, eosinophils, basophils, and neutrophils are GPR-9-6 negative. Transcripts of GPR-9-6 and TECK are present in both small intestine and thymus. Importantly, the expression profile of GPR-9-6 correlates with migration to TECK of blood T lymphocytes and thymocytes. As migration of these cells is blocked by anti–GPR-9-6 mAb 3C3, we conclude that GPR-9-6 is the principal chemokine receptor for TECK. In agreement with the nomenclature rules for chemokine receptors, we propose the designation CCR-9 for GPR-9-6. The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR-9-6/CCR-9, both in T cell development and the mucosal immune response.

#76 IL-1β changes G-protein coupled receptor kinase 2 levels and receptor sensitivity in the spinal cord

2005 ◽  
Vol 19 (4) ◽  
pp. e39-e40
Author(s):  
Wendy Kleibeuker ◽  
Annemieke Kavelaars ◽  
Freek L. van Muiswinkel ◽  
Cobi J. Heijnen
Keyword(s):  
Spinal Cord ◽  
G Protein ◽  
Receptor Kinase ◽  
Receptor Sensitivity ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure

1996 ◽  
Vol 1305 (1-2) ◽  
pp. 39-43 ◽  
Author(s):  
Aleksandra Roglić ◽  
Eric R. Prossnitz ◽  
Stacey L. Cavanagh ◽  
Zhixing Pan ◽  
Aihua Zou ◽  
...  
Keyword(s):  
G Protein ◽  
Cdna Cloning ◽  
Loop Structure ◽  
Extracellular Loop ◽  
G Protein Coupled Receptor ◽  
Large Extracellular Loop ◽  
G Protein Coupled

The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues

Gene ◽  
1995 ◽  
Vol 163 (2) ◽  
pp. 295-299 ◽  
Author(s):  
Carol J. Raport ◽  
Vicki L. Schweickart ◽  
Roger L. Eddy ◽  
Thomas B. Shows ◽  
Patrick W. Gray
Keyword(s):  
G Protein ◽  
Chemokine Receptors ◽  
G Protein Coupled Receptor ◽  
Neural Tissues ◽  
Encoding Gene ◽  
G Protein Coupled
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