Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat

Pain ◽  
1995 ◽  
Vol 62 (2) ◽  
pp. 219-231 ◽  
Author(s):  
S. W.N. Thompson ◽  
A. Dray ◽  
K. E. McCarson ◽  
J. E. Krause ◽  
L. Urban
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mechanical Allodynia ◽  
Receptor Activation ◽  
Spinal Reflex ◽  
Reflex Activity ◽  
Nerve Growth ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

scholarly journals Nerve Growth Factor Induces a Neurokinin-1 Receptor– Mediated Airway Hyperresponsiveness in Guinea Pigs

1999 ◽  
Vol 159 (5) ◽  
pp. 1541-1544 ◽  
Author(s):  
ANNICK de VRIES ◽  
MARK C. DESSING ◽  
FERDI ENGELS ◽  
PAUL A. J. HENRICKS ◽  
FRANS P. NIJKAMP
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Guinea Pigs ◽  
Airway Hyperresponsiveness ◽  
Nerve Growth ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

scholarly journals c-Jun/p38MAPK/ASIC3 pathways specifically activated by nerve growth factor through TrkA are crucial for mechanical allodynia development

Pain ◽  
2020 ◽  
Vol 161 (5) ◽  
pp. 1109-1123 ◽  
Author(s):  
Tanguy Chaumette ◽  
Lauriane Delay ◽  
Julie Barbier ◽  
Ludivine Boudieu ◽  
Youssef Aissouni ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mechanical Allodynia ◽  
Nerve Growth

Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia

Pain ◽  
2003 ◽  
Vol 104 (1) ◽  
pp. 241-247 ◽  
Author(s):  
Peter Svensson ◽  
Brian E. Cairns ◽  
Kelun Wang ◽  
Lars Arendt-Nielsen
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mechanical Allodynia ◽  
Masseter Muscle ◽  
Nerve Growth

scholarly journals Nerve Growth Factor Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes

2009 ◽  
Vol 68 (11) ◽  
pp. 1229-1243 ◽  
Author(s):  
Hsinlin T. Cheng ◽  
Jacqueline R. Dauch ◽  
John M. Hayes ◽  
Yu Hong ◽  
Eva L. Feldman
Keyword(s):  
Type 2 Diabetes ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Mechanical Allodynia ◽  
Nerve Growth

Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs

2002 ◽  
Vol 283 (2) ◽  
pp. L494-L502 ◽  
Author(s):  
Chengping Hu ◽  
Katrin Wedde-Beer ◽  
Alexander Auais ◽  
Maria M. Rodriguez ◽  
Giovanni Piedimonte
Keyword(s):  
Respiratory Syncytial Virus ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurogenic Inflammation ◽  
Receptor Expression ◽  
Sensory Nerves ◽  
Adult Rats ◽  
Nerve Growth ◽  
Syncytial Virus ◽  
Neurokinin 1

Nerve growth factor (NGF) controls sensorineural development and responsiveness and modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating the substance P receptor, neurokinin 1 (NK1). We investigated whether the expression of NGF and its trkA and p75 receptors in the lungs is age dependent, whether it is upregulated during RSV infection, and whether it affects neurogenic inflammation. Pathogen-free rats were killed at 2 (weanling) to 12 (adult) wk of age; in addition, subgroups of rats were inoculated with RSV or virus-free medium. In pathogen-free rats, expression of NGF and its receptors in the lungs declined with age, but RSV doubled expression of NGF, trkA, and p75 in weanling and adult rats. Exogenous NGF upregulated NK1 receptor expression in the lungs. Anti-NGF antibody inhibited NK1 receptor upregulation and neurogenic inflammation in RSV-infected lungs. These data indicate that expression of NGF and its receptors in the lungs declines physiologically with age but is upregulated by RSV and is a major determinant of neurogenic inflammation.

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