Characteristics of nerve growth factor induced hyperalgesia in adult rats: dependence on enhanced bradykinin-1 receptor activity but not neurokinin-1 receptor activation

Pain ◽  
1996 ◽  
Vol 66 (2) ◽  
pp. 359-372 ◽  
Author(s):  
Alain Rueff ◽  
Andrew J.L.R Dawson ◽  
Lorne M Mendell
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Receptor Activation ◽  
Receptor Activity ◽  
Adult Rats ◽  
Nerve Growth ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

scholarly journals Nerve Growth Factor Induces a Neurokinin-1 Receptor– Mediated Airway Hyperresponsiveness in Guinea Pigs

1999 ◽  
Vol 159 (5) ◽  
pp. 1541-1544 ◽  
Author(s):  
ANNICK de VRIES ◽  
MARK C. DESSING ◽  
FERDI ENGELS ◽  
PAUL A. J. HENRICKS ◽  
FRANS P. NIJKAMP
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Guinea Pigs ◽  
Airway Hyperresponsiveness ◽  
Nerve Growth ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs

2002 ◽  
Vol 283 (2) ◽  
pp. L494-L502 ◽  
Author(s):  
Chengping Hu ◽  
Katrin Wedde-Beer ◽  
Alexander Auais ◽  
Maria M. Rodriguez ◽  
Giovanni Piedimonte
Keyword(s):  
Respiratory Syncytial Virus ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurogenic Inflammation ◽  
Receptor Expression ◽  
Sensory Nerves ◽  
Adult Rats ◽  
Nerve Growth ◽  
Syncytial Virus ◽  
Neurokinin 1

Nerve growth factor (NGF) controls sensorineural development and responsiveness and modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating the substance P receptor, neurokinin 1 (NK1). We investigated whether the expression of NGF and its trkA and p75 receptors in the lungs is age dependent, whether it is upregulated during RSV infection, and whether it affects neurogenic inflammation. Pathogen-free rats were killed at 2 (weanling) to 12 (adult) wk of age; in addition, subgroups of rats were inoculated with RSV or virus-free medium. In pathogen-free rats, expression of NGF and its receptors in the lungs declined with age, but RSV doubled expression of NGF, trkA, and p75 in weanling and adult rats. Exogenous NGF upregulated NK1 receptor expression in the lungs. Anti-NGF antibody inhibited NK1 receptor upregulation and neurogenic inflammation in RSV-infected lungs. These data indicate that expression of NGF and its receptors in the lungs declines physiologically with age but is upregulated by RSV and is a major determinant of neurogenic inflammation.

Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats

Neuroscience ◽  
1993 ◽  
Vol 57 (3) ◽  
pp. 495-499 ◽  
Author(s):  
A. Nitta ◽  
K. Murase ◽  
Y. Furukawa ◽  
K. Hayashi ◽  
T. Hasegawa ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Continuous Infusion ◽  
Memory Impairment ◽  
Adult Rats ◽  
Nerve Growth ◽  
Neural Dysfunction

No nerve growth factor response to treatment with memantine in adult rats

2004 ◽  
Vol 111 (2) ◽  
pp. 181-190 ◽  
Author(s):  
U. E. Lang ◽  
M. M�hlbacher ◽  
M. B. Hesselink ◽  
W. Zajaczkowski ◽  
W. Danysz ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Response To Treatment ◽  
Adult Rats ◽  
Nerve Growth
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