Neurotransmitter release and synaptic vesicle recycling

Neuroscience ◽  
1990 ◽  
Vol 35 (3) ◽  
pp. 477-489 ◽  
Author(s):  
F. Valtorta ◽  
R. Fesce ◽  
F. Grohovaz ◽  
C. Haimann ◽  
W.P. Hurlbut ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Neurotransmitter Release ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling

scholarly journals Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

2019 ◽  
Vol 116 (23) ◽  
pp. 11113-11115 ◽  
Author(s):  
Jichao Sun ◽  
Lina Wang ◽  
Huan Bao ◽  
Sanjay Premi ◽  
Utpal Das ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Neurotransmitter Release ◽  
Unified Model ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling

The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn–VAMP2 interactions are necessary for α-syn–induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.

scholarly journals Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin

2010 ◽  
Vol 123 (7) ◽  
pp. 1131-1140 ◽  
Author(s):  
F. A. Meunier ◽  
T. H. Nguyen ◽  
C. Colasante ◽  
F. Luo ◽  
R. K. P. Sullivan ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Neurotransmitter Release ◽  
High Rate ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling
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