Staurosporine impairs both short-term and long-term potentiation in the dentate gyrus in vitro

Neuroscience ◽  
1994 ◽  
Vol 58 (2) ◽  
pp. 263-274 ◽  
Author(s):  
E. Hanse ◽  
B. Gustafsson
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Short Term ◽  
Term Potentiation

4-Hydroxynonenal modulates the long-term potentiation induced by L-type Ca2+ channel activation in the rat dentate gyrus in vitro

2004 ◽  
Vol 370 (2-3) ◽  
pp. 155-159 ◽  
Author(s):  
Tatsuhiro Akaishi ◽  
Ken Nakazawa ◽  
Kaoru Sato ◽  
Yasuo Ohno ◽  
Yoshihisa Ito
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Channel Activation ◽  
Term Potentiation

Conditions for the Induction of Long-Term Potentiation and Long-Term Depression by Conjunctive Pairing in the Dentate Gyrus In Vitro

1997 ◽  
Vol 78 (5) ◽  
pp. 2569-2573 ◽  
Author(s):  
Yue Wang ◽  
Jianqun Wu ◽  
Michael J. Rowan ◽  
Roger Anwyl
Keyword(s):  
Membrane Potential ◽  
Dentate Gyrus ◽  
Kinase Inhibitor ◽  
Long Term Potentiation ◽  
Ruthenium Red ◽  
Long Term Depression ◽  
Afferent Stimulation ◽  
Term Potentiation

Wang, Yue, Jianqun Wu, Michael J. Rowan, and Roger Anwyl. Conditions for the induction of long-term potentiation and long-term depression by conjunctive pairing in the dentate gyrus in vitro. J. Neurophysiol. 78: 2569–2573, 1997. The conditions under which long-term potentiation (LTP) and long-term depression (LTD) of excitatory postsynaptic currents were induced by the conjunctive pairing-type protocol of afferent stimulation and postsynaptic depolarization were studied in the medial perforant pathway-granule cell synapse of the dentate gyrus in vitro. The conjunctive pairing of 1-Hz afferent stimulation and steady state postsynaptic depolarization to 0 mV did not induce LTP or LTD. Inhibition of LTD induction with a phosphatase inhibitor or ruthenium red resulted in induction of LTP after the conjunctive pairing. Such LTP induction was N-methyl-d-aspartate dependent. Conversely, inhibition of LTP induction with a kinase inhibitor resulted in LTD induction after the conjunctive pairing. Thus the failure to induce LTP or LTD with the pairing protocol involving depolarization to 0 mV membrane potential was due to simultaneous activation of intracellular processes that generate the induction of LTP and LTD. Increasing the frequency of afferent stimulation to 200 Hz, even for just eight stimuli, resulted in LTP induction. The studies show that two factors govern the induction of LTP/LTD, membrane potential and frequency of afferent stimulation, with either increased depolarization or increased afferent stimulation favoring LTP induction.

scholarly journals Dentate gyrus granule cell firing patterns can induce mossy fiber long-term potentiation in vitro

Hippocampus ◽  
2010 ◽  
Vol 21 (11) ◽  
pp. 1157-1168 ◽  
Author(s):  
Rajen Mistry ◽  
Siobhan Dennis ◽  
Matthew Frerking ◽  
Jack R. Mellor
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Firing Patterns ◽  
Term Potentiation ◽  
Cell Firing

Long-Term Potentiation Is Mediated by Multiple Kinase Cascades Involving CaMKII or Either PKA or p42/44 MAPK in the Adult Rat Dentate Gyrus In Vitro

2006 ◽  
Vol 95 (6) ◽  
pp. 3519-3527 ◽  
Author(s):  
Jianqun Wu ◽  
Michael J. Rowan ◽  
Roger Anwyl
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Mek Inhibitor ◽  
Dependent Protein Kinase ◽  
Adult Rats ◽  
Adult Rat ◽  
Term Potentiation ◽  
Dependent Protein

The induction of NMDA-receptor–dependent long-term potentiation (LTP) in adult CA1 is contingent on activation of Ca/calmodulin-dependent protein kinase II (CaMKII). However, little is known about kinase mediation of LTP in the dentate gyrus. In the present study, the involvement of the kinases CaMKII, PKA, and MAPK in the induction of LTP was studied in the dentate gyrus of adult rats. Individual application of selective inhibitors of CaMKII, MEK, or PKA did not inhibit induction of LTP. In contrast, coapplication of a CaMKII inhibitor with either a PKA or MEK inhibitor resulted in a strong block of LTP. Induction of LTP was blocked by the coapplication of the inhibitors CaMKII and PKA or MEK, both when they were applied 1 h before the induction stimulus and also when they were applied after the induction stimulus. Thus LTP is mediated by either of two parallel cascades, one involving CaMKII and the other PKA or MAPK. Moreover, these cascades are active for a certain period after the induction stimulus.

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