The relationship of the dexamethasone suppression test (1 mg and 2 mg) to basal plasma cortisol levels in endogenous depression

1987 ◽  
Vol 12 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Gregory M. Asnis ◽  
Uriel Halbreich ◽  
Neal D. Ryan ◽  
Harry Rabinowicz ◽  
Joaquim Puig-Antich ◽  
...  
Keyword(s):  
Plasma Cortisol ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Basal Plasma ◽  
Suppression Test ◽  
Cortisol Levels ◽  
Relationship Of ◽  
The Relationship ◽  
Dexamethasone Suppression

scholarly journals Association between posttest dexamethasone and cortisol concentrations in the 1 mg overnight dexamethasone suppression test

2012 ◽  
Vol 1 (2) ◽  
pp. 62-67 ◽  
Author(s):  
Bjørn O Åsvold ◽  
Valdemar Grill ◽  
Ketil Thorstensen ◽  
Marit R Bjørgaas
Keyword(s):  
Cushing’S Syndrome ◽  
Plasma Cortisol ◽  
Polynomial Regression ◽  
Regression Line ◽  
Cushing's Syndrome ◽  
Dexamethasone Suppression Test ◽  
Strong Negative Association ◽  
Suppression Test ◽  
Cortisol Levels ◽  
Dexamethasone Suppression

It has been suggested that comparison of posttest dexamethasone and cortisol concentrations may improve the evaluation of the dexamethasone suppression test (DST) for Cushing's syndrome. In particular, this would be reasonable if posttest cortisol differs by dexamethasone levels within the range that is usually attained in the DST. Using fractional polynomial regression, we therefore studied the association between posttest 0800 h dexamethasone and cortisol levels in 53 subjects without Cushing's syndrome who were tested with the 1 mg overnight DST. Plasma dexamethasone was associated with plasma cortisol (P<0.001), and the regression line suggested a strong negative association related to dexamethasone levels <5 nmol/l. However, among the 94% of subjects with plasma dexamethasone >5.0 nmol/l, there was no association between dexamethasone and cortisol levels (P=0.55). In conclusion, subjects tested with the 1 mg overnight DST usually attain an 0800 h plasma dexamethasone >5 nmol/l, and plasma cortisol does not differ by plasma dexamethasone in these subjects. This suggests that routine comparison of dexamethasone and cortisol levels may not be a useful approach to improve the performance of the 1 mg DST. However, dexamethasone measurements may identify subjects with inadequately low plasma dexamethasone and may therefore be of value when retesting subjects with possibly false-positive DST results.

Clinical use of the DST in a Psychogeriatric Population

1984 ◽  
Vol 145 (4) ◽  
pp. 389-393 ◽  
Author(s):  
Ian G. McKeith
Keyword(s):  
Plasma Cortisol ◽  
Senile Dementia ◽  
The Elderly ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Clinical Implications ◽  
Clinical Use ◽  
Suppression Test ◽  
Confusional States ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test (DST) was administered to 95 patients referred to a psychogeriatric assessment service. Non-suppression of plasma cortisol was found in 28 out of 48 patients (58%) with senile dementia and all patients with arteriosclerotic dementia or acute confusional states. Non-suppression could not be explained by associated depressive symptoms. The DST was confirmed as a valid diagnostic test for endogenous depression in the elderly, but its value in distinguishing true dementing illnesses from depressive pseudodementia was not supported. The clinical implications of these findings for interpreting DST results in the elderly are discussed.

Dexamethasone Concentrations and the Dexamethasone Suppression Test in Psychiatric Disorders

1986 ◽  
Vol 148 (1) ◽  
pp. 66-69 ◽  
Author(s):  
Howard Morris ◽  
Vaughan Carr ◽  
Judy Gilliland ◽  
Michael Hooper
Keyword(s):  
Psychiatric Disorders ◽  
Clinical Diagnosis ◽  
Serum Cortisol ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Suppression Test ◽  
Cortisol Levels ◽  
High Concentrations ◽  
Dexamethasone Suppression ◽  
Low Serum

The dexamethasone suppression test (DST) has been widely used in psychiatry as a laboratory aid for the diagnosis of endogenous depression; failure to suppress serum cortisol levels is interpreted as confirming a clinical diagnosis of endogenous depression. We found that serum dexamethasone concentrations in this test vary widely and are determinants of the DST response: non-suppression of serum cortisol levels is associated with low serum dexamethasone concentrations, and suppression is associated with high concentrations.

The Dexamethasone Suppression Test as a Discriminator among Subtypes of Psychotic Patients

1982 ◽  
Vol 141 (5) ◽  
pp. 471-474 ◽  
Author(s):  
Anthony J. Rothschild ◽  
Alan F. Schatzberg ◽  
Alan H. Rosenbaum ◽  
Julie B. Stahl ◽  
Jonathan O. Cole
Keyword(s):  
Plasma Cortisol ◽  
Bipolar Depression ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Control Subjects ◽  
Distribution Of Values ◽  
Suppression Test ◽  
Cortisol Levels ◽  
Dexamethasone Suppression

SummaryPlasma Cortisol levels examined at 16.00 hours after dexamethasone in 31 controls and in 34 psychotic patients with various diagnoses, suggests that the ranges of such levels may help to discriminate among subtypes of psychotic patients. They were significantly higher in the unipolar depressed psychotic group than in control subjects or in psychotic patients with bipolar depression or schizophrenia. Moreover, the distribution of values differed between groups. Whereas 8 of 14 psychotic patients with unipolar depressive illness had post-dexamethasone Cortisol values ≥ 14 μg/dl, none of the remaining psychotic patients had similarly high values. Implications of these data are discussed.

An American Validation Study of the Newcastle Diagnostic Scale: I. Relationship with the Dexamethasone Suppression Test

1986 ◽  
Vol 149 (5) ◽  
pp. 627-630 ◽  
Author(s):  
M. Zimmerman ◽  
B. Pfohl ◽  
D. Stangl ◽  
W. Coryell
Keyword(s):  
Validation Study ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Non Linear ◽  
Hospital Patients ◽  
Suppression Test ◽  
The Relationship ◽  
Dexamethasone Suppression ◽  
Diagnostic Index

The Newcastle diagnostic index was completed on 159 depressedin-patients, who received the dexamethasone suppression test during their first week in hospital. Patients suffering from endogenous depression had a significantly higher rate of DST non-suppression, were older, were more frequently psychotic, and more frequently lost weight; even after con trolling for these variables, DST non-suppression was significantly more frequent in the endogenous group. The relationship between Newcastle scores and the frequency of DST non-suppression was non-linear.

Are depression and denutrition good predictors of dexamethasone suppression test (DST) in anorexia nervosa?

1998 ◽  
Vol 13 (8) ◽  
pp. 411-418 ◽  
Author(s):  
C Massoubre ◽  
F Lang ◽  
L Millot ◽  
M Pichon ◽  
B Estour ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Stepwise Regression ◽  
Serum Cortisol ◽  
Dexamethasone Suppression Test ◽  
Stepwise Logistic Regression ◽  
Independent Variables ◽  
Suppression Test ◽  
Depression Scales ◽  
The Relationship ◽  
Dexamethasone Suppression

SummaryThis study was conducted to investigate the corticotropic axis in anorexia nervosa. In 93 female inpatients who met DSM-III-R criteria for anorexia nervosa, subsample (n = 64) with DSM-III criteria was also considered. Using stepwise regression analysis, this study examined the relationship between independent variables ie, age, body mass index, scores on depression scales and postdexamethasone serum cortisol, considered as a dependent variable. In patients who met DSM-III criteria, 16.7% of the variance of serum cortisol can be explained. The main predictors are depressive retardation, emaciation and age. Using stepwise logistic regression the main categorical predictors of the test suppression vs non suppression are of the same nature. The condition of realisation of DST are discussed.

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