The relationship of the dexamethasone suppression test to subtypes of depression and to symptomatic severity in the elderly

1986 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
A GEORGOTAS ◽  
P STOKES ◽  
W HAPWORTH ◽  
O MARYKIM ◽  
C FANELLI ◽  
...  
Keyword(s):  
The Elderly ◽  
Dexamethasone Suppression Test ◽  
Suppression Test ◽  
Relationship Of ◽  
The Relationship ◽  
Dexamethasone Suppression

Are depression and denutrition good predictors of dexamethasone suppression test (DST) in anorexia nervosa?

1998 ◽  
Vol 13 (8) ◽  
pp. 411-418 ◽  
Author(s):  
C Massoubre ◽  
F Lang ◽  
L Millot ◽  
M Pichon ◽  
B Estour ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Stepwise Regression ◽  
Serum Cortisol ◽  
Dexamethasone Suppression Test ◽  
Stepwise Logistic Regression ◽  
Independent Variables ◽  
Suppression Test ◽  
Depression Scales ◽  
The Relationship ◽  
Dexamethasone Suppression

SummaryThis study was conducted to investigate the corticotropic axis in anorexia nervosa. In 93 female inpatients who met DSM-III-R criteria for anorexia nervosa, subsample (n = 64) with DSM-III criteria was also considered. Using stepwise regression analysis, this study examined the relationship between independent variables ie, age, body mass index, scores on depression scales and postdexamethasone serum cortisol, considered as a dependent variable. In patients who met DSM-III criteria, 16.7% of the variance of serum cortisol can be explained. The main predictors are depressive retardation, emaciation and age. Using stepwise logistic regression the main categorical predictors of the test suppression vs non suppression are of the same nature. The condition of realisation of DST are discussed.

Clinical use of the DST in a Psychogeriatric Population

1984 ◽  
Vol 145 (4) ◽  
pp. 389-393 ◽  
Author(s):  
Ian G. McKeith
Keyword(s):  
Plasma Cortisol ◽  
Senile Dementia ◽  
The Elderly ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Clinical Implications ◽  
Clinical Use ◽  
Suppression Test ◽  
Confusional States ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test (DST) was administered to 95 patients referred to a psychogeriatric assessment service. Non-suppression of plasma cortisol was found in 28 out of 48 patients (58%) with senile dementia and all patients with arteriosclerotic dementia or acute confusional states. Non-suppression could not be explained by associated depressive symptoms. The DST was confirmed as a valid diagnostic test for endogenous depression in the elderly, but its value in distinguishing true dementing illnesses from depressive pseudodementia was not supported. The clinical implications of these findings for interpreting DST results in the elderly are discussed.

An American Validation Study of the Newcastle Diagnostic Scale: I. Relationship with the Dexamethasone Suppression Test

1986 ◽  
Vol 149 (5) ◽  
pp. 627-630 ◽  
Author(s):  
M. Zimmerman ◽  
B. Pfohl ◽  
D. Stangl ◽  
W. Coryell
Keyword(s):  
Validation Study ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Non Linear ◽  
Hospital Patients ◽  
Suppression Test ◽  
The Relationship ◽  
Dexamethasone Suppression ◽  
Diagnostic Index

The Newcastle diagnostic index was completed on 159 depressedin-patients, who received the dexamethasone suppression test during their first week in hospital. Patients suffering from endogenous depression had a significantly higher rate of DST non-suppression, were older, were more frequently psychotic, and more frequently lost weight; even after con trolling for these variables, DST non-suppression was significantly more frequent in the endogenous group. The relationship between Newcastle scores and the frequency of DST non-suppression was non-linear.

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