scholarly journals Second primary cancers following initial treatment of patients with head and neck cancers

1986 ◽  
Vol 12 ◽  
pp. 110
Author(s):  
Robert G. Parker ◽  
James E. Enstrom
Keyword(s):  
Head And Neck ◽  
Initial Treatment ◽  
Head And Neck Cancers ◽  
Second Primary ◽  
Second Primary Cancers

scholarly journals Effect of Metformin on Progression of Head and Neck Cancers, Occurrence of Second Primary Cancers, and Cause‐Specific Survival

2015 ◽  
Vol 20 (5) ◽  
pp. 546-553 ◽  
Author(s):  
Minsu Kwon ◽  
Jong‐Lyel Roh ◽  
Jihyun Song ◽  
Sang‐Wook Lee ◽  
Sung‐Bae Kim ◽  
...  
Keyword(s):  
Head And Neck ◽  
Head And Neck Cancers ◽  
Second Primary ◽  
Second Primary Cancers ◽  
Cause Specific Survival

scholarly journals Developing a Stacked Ensemble-Based Classification Scheme to Predict Second Primary Cancers in Head and Neck Cancer Survivors

2021 ◽  
Vol 18 (23) ◽  
pp. 12499
Author(s):  
Chi-Chang Chang ◽  
Tse-Hung Huang ◽  
Pei-Wei Shueng ◽  
Ssu-Han Chen ◽  
Chun-Chia Chen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Classification Scheme ◽  
Area Under The Curve ◽  
Primary Site ◽  
Second Primary ◽  
Second Primary Cancer ◽  
Second Primary Cancers ◽  
N Status

Despite a considerable expansion in the present therapeutic repertoire for other malignancy managements, mortality from head and neck cancer (HNC) has not significantly improved in recent decades. Moreover, the second primary cancer (SPC) diagnoses increased in patients with HNC, but studies providing evidence to support SPCs prediction in HNC are lacking. Several base classifiers are integrated forming an ensemble meta-classifier using a stacked ensemble method to predict SPCs and find out relevant risk features in patients with HNC. The balanced accuracy and area under the curve (AUC) are over 0.761 and 0.847, with an approximately 2% and 3% increase, respectively, compared to the best individual base classifier. Our study found the top six ensemble risk features, such as body mass index, primary site of HNC, clinical nodal (N) status, primary site surgical margins, sex, and pathologic nodal (N) status. This will help clinicians screen HNC survivors before SPCs occur.

scholarly journals Effectiveness of planned surveillance for detecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma

2020 ◽  
Vol 50 (10) ◽  
pp. 1162-1167 ◽  
Author(s):  
Takeshi Shinozaki ◽  
Chikatoshi Katada ◽  
Kiyoto Shiga ◽  
Takahiro Asakage ◽  
Tetsuji Yokoyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Endoscopic Resection ◽  
Squamous Cell ◽  
Head And Neck Cancers ◽  
Transoral Surgery ◽  
Second Primary ◽  
Laryngeal Function

Abstract Background Second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma adversely affect patients’ outcomes and the quality of life; however, an adequate surveillance schedule remains unclear. Methods We analyzed 330 patients with early esophageal squamous cell carcinoma who underwent endoscopic resection and were registered in the multicenter cohort study to evaluate adequate surveillance for detection of second primary head and neck cancers. Gastrointestinal endoscopists examined the head and neck regions after 3–6 months of endoscopic resection for esophageal squamous cell carcinoma and subsequently every 6 months. An otolaryngologist also examined the head and neck regions at the time of endoscopic resection for esophageal squamous cell carcinoma and at 12 months intervals thereafter. Results During the median follow-up period of 49.4 months (1.3–81.2 months), 33 second primary head and neck cancers were newly detected in 20 patients (6%). The tumor site was as follows: 22 lesions in the hypopharynx, eight lesions in the oropharynx, two lesions in larynx and one lesion in the oral cavity. The 2-year cumulative incidence rate of second primary head and neck cancers was 3.7%. Among them, 17 patients with 29 lesions were treated by transoral surgery. One patient with two synchronous lesions was treated by radiotherapy. Two lesions in two patients were not detected after biopsy. All patients were cured with preserved laryngeal function. Conclusions Surveillance by gastrointestinal endoscopy every 6 months and surveillance by an otolaryngologist every 12 months could detect second primary head and neck cancers at an early stage, thereby facilitating minimally invasive treatment.

Re-irradiation for recurrent and second primary cancers of the head and neck

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 46-51 ◽  
Author(s):  
Maria A. Velez ◽  
Darlene Veruttipong ◽  
Pin-Chieh Wang ◽  
Robert Chin ◽  
Philip Beron ◽  
...  
Keyword(s):  
Head And Neck ◽  
Second Primary ◽  
Second Primary Cancers

scholarly journals Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pariyada Tanjak ◽  
Bhoom Suktitipat ◽  
Nutchavadee Vorasan ◽  
Panudeth Juengwiwattanakitti ◽  
Benjarat Thiengtrong ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cancer Development ◽  
Multiple Primary Cancers ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancers ◽  
Genital Cancer ◽  
Multiple Primary ◽  
Female Genital ◽  
Male Genital

Abstract Background The situation of patients developing multiple primary cancers is becoming more frequent and graver. This study investigated the risks of developing second primary cancers that are related to first primary cancers, and the interval times of synchronous and metachronous multiple primary cancers. Patients and methods Retrospective data were retrieved from 109,054 patients aged ≥18 who were diagnosed with a first solid cancer and registered at Siriraj Cancer Center between 1991 and 2015. A two-month period between first- and second- primary cancers was used to differentiate metachronous and synchronous multiple primary cancers. The combinations of subsequent cancers and relative risks (RRs) of having multiple primary cancers versus having single primary cancer for the top-ten first and second primary cancers were examined. The RR was adjusted for age of the first primary cancer. A survival analysis of the time to second-primary-cancer development was performed. Results Multiple primary cancers were found in 1785 (1.63%) patients. Most (70.87%) second primary cancers occurred after 2 months of first breast, skin, colorectal, lung, head and neck, liver, male genital cancer–prostate, thyroid, and female genital cancer–non-uterine cancers, resulting in those cancers being classified as metachronous multiple primary cancer. After adjustment for age at first diagnosis, head and neck cancers had the highest metachronous association with second esophageal cancers (RR, 25.06; 95% CI, 13.41–50.77). Prostate cancer and second colorectal cancer also demonstrated a high metachronous association (RR, 2.00; 95% CI, 1.25–3.05). A strong synchronous association was found between uterine and ovarian cancers (RR, 27.77; 95% CI, 17.97–43.63). The median time from the first uterine cancer to second-cancer development was 55 days. Conclusions The top-ten most frequent multiple primary cancers were the following: breast; liver; head and neck; colorectal; male genital cancer–prostate; skin; female genital cancer–uterine; thyroid; lung; and female genital cancer–non-uterine. Second primary cancers showed specific associations that depended on the first primary cancer. Physicians should be cognizant of the most common combinations and the interval times of metachronous and synchronous multiple primary cancers.

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