scholarly journals Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pariyada Tanjak ◽  
Bhoom Suktitipat ◽  
Nutchavadee Vorasan ◽  
Panudeth Juengwiwattanakitti ◽  
Benjarat Thiengtrong ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cancer Development ◽  
Multiple Primary Cancers ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancers ◽  
Genital Cancer ◽  
Multiple Primary ◽  
Female Genital ◽  
Male Genital

Abstract Background The situation of patients developing multiple primary cancers is becoming more frequent and graver. This study investigated the risks of developing second primary cancers that are related to first primary cancers, and the interval times of synchronous and metachronous multiple primary cancers. Patients and methods Retrospective data were retrieved from 109,054 patients aged ≥18 who were diagnosed with a first solid cancer and registered at Siriraj Cancer Center between 1991 and 2015. A two-month period between first- and second- primary cancers was used to differentiate metachronous and synchronous multiple primary cancers. The combinations of subsequent cancers and relative risks (RRs) of having multiple primary cancers versus having single primary cancer for the top-ten first and second primary cancers were examined. The RR was adjusted for age of the first primary cancer. A survival analysis of the time to second-primary-cancer development was performed. Results Multiple primary cancers were found in 1785 (1.63%) patients. Most (70.87%) second primary cancers occurred after 2 months of first breast, skin, colorectal, lung, head and neck, liver, male genital cancer–prostate, thyroid, and female genital cancer–non-uterine cancers, resulting in those cancers being classified as metachronous multiple primary cancer. After adjustment for age at first diagnosis, head and neck cancers had the highest metachronous association with second esophageal cancers (RR, 25.06; 95% CI, 13.41–50.77). Prostate cancer and second colorectal cancer also demonstrated a high metachronous association (RR, 2.00; 95% CI, 1.25–3.05). A strong synchronous association was found between uterine and ovarian cancers (RR, 27.77; 95% CI, 17.97–43.63). The median time from the first uterine cancer to second-cancer development was 55 days. Conclusions The top-ten most frequent multiple primary cancers were the following: breast; liver; head and neck; colorectal; male genital cancer–prostate; skin; female genital cancer–uterine; thyroid; lung; and female genital cancer–non-uterine. Second primary cancers showed specific associations that depended on the first primary cancer. Physicians should be cognizant of the most common combinations and the interval times of metachronous and synchronous multiple primary cancers.

scholarly journals Incidence of multiple primary cancers and interval between first and second primary cancers

2014 ◽  
Vol 105 (7) ◽  
pp. 890-896 ◽  
Author(s):  
Mai Utada ◽  
Yuko Ohno ◽  
Megumi Hori ◽  
Midori Soda
Keyword(s):  
Multiple Primary Cancers ◽  
Second Primary ◽  
Second Primary Cancers ◽  
Multiple Primary

scholarly journals Developing a Stacked Ensemble-Based Classification Scheme to Predict Second Primary Cancers in Head and Neck Cancer Survivors

2021 ◽  
Vol 18 (23) ◽  
pp. 12499
Author(s):  
Chi-Chang Chang ◽  
Tse-Hung Huang ◽  
Pei-Wei Shueng ◽  
Ssu-Han Chen ◽  
Chun-Chia Chen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Classification Scheme ◽  
Area Under The Curve ◽  
Primary Site ◽  
Second Primary ◽  
Second Primary Cancer ◽  
Second Primary Cancers ◽  
N Status

Despite a considerable expansion in the present therapeutic repertoire for other malignancy managements, mortality from head and neck cancer (HNC) has not significantly improved in recent decades. Moreover, the second primary cancer (SPC) diagnoses increased in patients with HNC, but studies providing evidence to support SPCs prediction in HNC are lacking. Several base classifiers are integrated forming an ensemble meta-classifier using a stacked ensemble method to predict SPCs and find out relevant risk features in patients with HNC. The balanced accuracy and area under the curve (AUC) are over 0.761 and 0.847, with an approximately 2% and 3% increase, respectively, compared to the best individual base classifier. Our study found the top six ensemble risk features, such as body mass index, primary site of HNC, clinical nodal (N) status, primary site surgical margins, sex, and pathologic nodal (N) status. This will help clinicians screen HNC survivors before SPCs occur.

Multiple Primary Cancers of the Head and Neck.

1996 ◽  
Vol 89 (11) ◽  
pp. 1383-1388
Author(s):  
Eiji Takahashi ◽  
Tomoo SUZUKI ◽  
Yatsuji Ito ◽  
Keisuke MIZUTA ◽  
Shinji SAKUMA ◽  
...  
Keyword(s):  
Head And Neck ◽  
Multiple Primary Cancers ◽  
Multiple Primary

scholarly journals MULTIPLE PRIMARY CANCERS IN PATIENTS WITH HEAD AND NECK CANCER AND HISTORY OF TOBACCO SMOKING AND DRINKING

1993 ◽  
Vol 96 (9) ◽  
pp. 1501-1509,1579 ◽  
Author(s):  
MUNENAGA NAKAMIZO ◽  
SIN'ETSU KAMATA ◽  
KAZUYOSHI KAWABATA ◽  
HISAAKI TAKAHASHI ◽  
TOMOHIKO NIGAURI ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tobacco Smoking ◽  
Multiple Primary Cancers ◽  
Multiple Primary ◽  
History Of

Trends over three decades of the risk of second primary cancer among patients with head and neck cancer

Oral Oncology ◽  
2013 ◽  
Vol 49 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Jérémie Jégu ◽  
Florence Binder-Foucard ◽  
Christian Borel ◽  
Michel Velten
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Development of second primary cancers in breast cancer survivors.

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 257-257
Author(s):  
Hong Kyu Jung ◽  
Jihyoun Lee ◽  
Zisun Kim ◽  
Min Hyuk Lee ◽  
Ilkyun Lee
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
Thyroid Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Breast Cancer Patients ◽  
Second Primary Cancers

257 Background: Breast cancer survivors have slightly increased risk of second primary cancers. Importance of screening for second cancers has been raised due to increased survival in those populations. Not only having genetic risk such as BRCA mutation, but also treatment-related risk presents. The most common second primary cancer is breast cancer. Colon cancer, uterine cancer, and ovarian cancer showed increased cumulative incidence. In this study, we assessed development second primary cancers in breast cancer survivors. Methods: Medical record of breast cancer patients was reviewed retrospectively in three tertiary medical institutions. Available data of ICD-9 record after breast cancer diagnosis was evaluated. Diagnosis of second primary breast cancer was excluded in evaluation. Results: Since Jan 1989 to Jan 2014, available medical records were reviewed in breast cancer patients(N = 5880) in three institutions(one urban and the other two rural institutions). Cumulative incidence of overall second primary cancers was 4.57%. Among 269 second primary cancers, thyroid cancer(44.2%) was most common second primary cancer, followed by gastric cancer(10.0%). Gastric cancers were more common in rural institution than urban area(14.2 % vs 5.5%), while incidence of thyroid cancer is elevated in urban institution(57.8% vs 31.9%). Among 9 patients who has been diagnosed endometrial cancer, 7 patients had history of selective estrogen receptor modulator(tamoxifen or toremifen) treatment. Development of lung cancer was not related to breast cancer radiation treatment(4 of 15 patients). Leukemia after breast cancer treatment was diagnosed in 5 patients (8.5% of second primary cancers), three of them were adult T cell leukemia and two of them were acute myeloid leukemia. Conclusions: Incidence of cancer in general population was reflected to development of second primary cancer in breast cancer survivors. Endocrine treatment was related increased incidence of endometrial cancer, respectively. Application of personalized cancer screening plan would be important in this patient group.

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