The paper presents a detailed algorithm for calculating the vapor-liquid phase equilibrium for multicomponent systems based on the Peng-Robinson equation of state. Various approaches are considered that make it possible to improve the quality of predicting phase equilibrium by the example of eight binary helium systems containing nitrogen, argon, carbon dioxide, methane, ethane, propane, isobutane, and n-butane. The influence of the acentric factor and the binary interaction parameter on the accuracy of the helium systems phase behavior predicting is analyzed. The optimal interaction coefficients for the presented systems are found under the assumption that this parameter does not depend on temperature. The temperature range of applicability of various approaches is determined, which makes it possible to maximize the description of the phase behavior of helium systems.