How can clinicians choose between conflicting and discordant systematic reviews? A replication study of the Jadad algorithm

Introduction: The exponential growth of published SRs (SRs) presents challenges for clinicians seeking to answer clinical questions. In 1997, an algorithm was created by Jadad et al. to choose the best SR across multiple but similar SRs with conflicting results. Our study aims to replicate assessments done by authors using the Jadad algorithm to determine: (i) if we chose the same SR as the authors; and (ii) if we would reach the same results.Methods and Analysis: We searched MEDLINE, Epistemonikos, and Cochrane Database of SRs. We included any study using the Jadad algorithm. We used consensus building strategies to operationalise the algorithm and to ensure a consistent approach to interpretation.Results: We identified 21 studies that used the Jadad algorithm to choose one or more SRs. In 62% (13/21) of cases, we were unable to replicate the Jadad assessment and ultimately chose a different SR than the authors. Overall, 18 out of the 21 (86%) independent Jadad assessments agreed in direction of the findings despite 13 having chosen a different SR.Conclusions: Our results suggest that the Jadad algorithm is not reproducible between users as there are no prescriptive instructions about how to operationalise the algorithm. In the absence of a validated algorithm, we recommend that healthcare providers, policy makers, patients and researchers address conflicts between review findings by choosing the SR(s) with meta-analysis of RCTs that most closely resemble their clinical, public health, or policy question, are the most recent, comprehensive (i.e. in terms of number of included RCTs), and at the lowest risk of bias.

sandbox – Creating and Analysing Synthetic Sediment Sections with R

The majority of palaeoenvironmental information is inferred from proxy data contained in accretionary sediments, called geo-archives. The validity of proxy data and analysis workflows are usually assumed implicitly, with systematic tests and uncertainty estimates restricted to modern analogue studies or reduced-complexity case studies. However, a more generic and consistent approach to exploring the validity and variability of proxy functions would be to translate a given geo-archive into a model scenario: a "virtual twin". Here, we introduce a conceptual framework and numerical toolset that allows the definition and analysis of synthetic sediment sections. The R package sandbox describes arbitrary stratigraphically consistent deposits by depth-dependent rules and grain-specific parameters, allowing full scalability and flexibility. Virtual samples can be taken, resulting in discrete grain-mixtures with well-defined parameters. These samples can then be virtually prepared and analysed, for example to test hypotheses. We illustrate the concept of sandbox, explain how a sediment section can be mapped into the model and, by focusing on an exemplary field of application, we explore universal geochronological research questions related to the effects of sample geometry and grain-size specific age inheritance. We summarise further application scenarios of the model framework, relevant for but not restricted to the broader geochronological community.

A Systematic Search for Dual AGNs in Merging Galaxies (Astro-daring): III: Results from the SDSS Spectroscopic Surveys

As the third installment in a series systematically searching dual active galactic nuclei (AGN) among merging galaxies, we present the results of 20 dual AGNs found by using the SDSS fiber spectra. To reduce the flux contamination from both the fiber aperture and seeing effects, the angular separation of two cores in our merging galaxy pairs sample is restricted at least larger than 3″. By careful analysis of the emission lines, 20 dual AGNs are identified from 61 merging galaxies with their two cores both observed by the SDSS spectroscopic surveys. 15 of them are identified for the first time. The identification efficiency is about 32.79% (20/61), comparable to our former results (16 dual AGNs identified from 41 merging galaxies) based on the long-slit spectroscopy. Interestingly, two of the 20 dual AGNs show two prominent cores in radio images and their radio powers show they as the radio-excess AGNs. So far, 31 dual AGNs are found by our project and this is the current largest dual AGN sample, ever constructed with a consistent approach. This sample, together with more candidates from ongoing observations, is of vital importance to study the AGN physics and the coevolution between the supermassive black holes and their host galaxies.

Approximate Noether Symmetries of Perturbed Lagrangians and Approximate Conservation Laws

In this paper, within the framework of the consistent approach recently introduced for approximate Lie symmetries of differential equations, we consider approximate Noether symmetries of variational problems involving small terms. Then, we state an approximate Noether theorem leading to the construction of approximate conservation laws. Some illustrative applications are presented.

Te Reo Maori as a Language of New Zealand Law: The Attainment of Civic Status

<p>In July 2011 the Waitangi Tribunal released Wai 262, its report on the indigenous flora and fauna claim. In the report, the Tribunal signalled "a deep-seated fear for the survival of te reo" and found that the language was in a state of "renewed decline". To date, revitalisation initiatives have focussed largely on stemming language decline in the community. Comparatively little attention has been given to the need to develop te reo Māori in the civic life of the state; in particular, as a language of law and legal process. This dissertation argues that if te reo Māori is to survive in the 21st century, it must develop as a fully functional language of New Zealand law. This dissertation critiques the domestic and international instruments that protect the right to use te reo Māori in civic contexts, and identifies three developments that are necessary for te reo Māori to achieve full functionality as a legal language. The first is the provision of an unqualified right to use Māori in the law-making process. The second is the use of Māori in the substantive enactment of law. The third is a principled and consistent approach to drafting and interpreting Māori words and provisions in statutes.</p>

Te Reo Maori as a Language of New Zealand Law: The Attainment of Civic Status

<p>In July 2011 the Waitangi Tribunal released Wai 262, its report on the indigenous flora and fauna claim. In the report, the Tribunal signalled "a deep-seated fear for the survival of te reo" and found that the language was in a state of "renewed decline". To date, revitalisation initiatives have focussed largely on stemming language decline in the community. Comparatively little attention has been given to the need to develop te reo Māori in the civic life of the state; in particular, as a language of law and legal process. This dissertation argues that if te reo Māori is to survive in the 21st century, it must develop as a fully functional language of New Zealand law. This dissertation critiques the domestic and international instruments that protect the right to use te reo Māori in civic contexts, and identifies three developments that are necessary for te reo Māori to achieve full functionality as a legal language. The first is the provision of an unqualified right to use Māori in the law-making process. The second is the use of Māori in the substantive enactment of law. The third is a principled and consistent approach to drafting and interpreting Māori words and provisions in statutes.</p>