Characterization of adsorption behavior by solid dosage form excipients in formulation development

Alogliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor for oral diabetes care. The present study aims to evaluate the compatibility of alogliptin benzoate with the extensively used pharmaceutical excipients for solid dosage form. This can be achieved by applying Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) techniques together with Fourier-Transform Infrared spectroscopy (FT-IR) as paired technique to aid in the interpretation of outcome. Chosen excipients were Cross carmellose sodium, microcrystalline cellulose, magnesium stearate, sodium starch glycolate, and pregelatinised starch. Results illustrated that drug was compatible with all the excipients except magnesium stearate where a slight degree of physical interaction was observed but mass loss due to degradation was not hastened in TGA. FT-IR study lined out any chemical change of drug with magnesium stearate. These results would be valuable for formulation development of the film coated tablets of alogliptin benzoate.

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Production and In Vitro Characterization of Solid Dosage form Incorporating Drug Nanoparticles

Drug Development and Industrial Pharmacy ◽

10.1080/03639040802005024 ◽

2008 ◽

Vol 34 (11) ◽

pp. 1209-1218 ◽

Cited By ~ 73

Author(s):

Shradhanjali Basa ◽

Thilekkumar Muniyappan ◽

Pradeep Karatgi ◽

Raghavendra Prabhu ◽

Ravi Pillai

Keyword(s):

Dosage Form ◽

Solid Dosage Form ◽

Solid Dosage ◽

Drug Nanoparticles ◽

In Vitro Characterization

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A comprehensive review on pharmaceutical mini tablets

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i6.2060 ◽

2018 ◽

Vol 8 (6) ◽

pp. 382-390 ◽

Cited By ~ 1

Author(s):

Priyanka Priyanka ◽

Kapil Kumar ◽

Deepak Teotia

Keyword(s):

Dosage Form ◽

Dosage Forms ◽

Oral Dosage ◽

Formulation Development ◽

Coating Materials ◽

Solid Dosage Form ◽

Solid Dosage ◽

Therapeutic Benefits ◽

Form Design ◽

Oral Dosage Forms

Mini-tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less. Offering some therapeutic benefits such as dose flexibility and combined release patterns. They do not require any solvent for their production and also local irritation can be avoided by the use of mini tablet Mini tablet offer several advantages like they can be manufactured relatively easily, They are not require less coating materials and also there is a great flexibility during their formulation development. Mini tablet are more acceptable in children and elderly people as they are easy to swallow. The objective of controlled drug delivery systems is to reduce the frequency of the dosing and to increase the effectiveness of the drug by localization. Keywords: Mini-tablets, solid dosage form, oral dosage forms.

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