COMPATIBILITY STUDY OF ALOGLIPTIN BENZOATE WITH WIDELY USED PHARMACEUTICAL EXCIPIENTS FOR SOLID DOSAGE FORM

Alogliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor for oral diabetes care. The present study aims to evaluate the compatibility of alogliptin benzoate with the extensively used pharmaceutical excipients for solid dosage form. This can be achieved by applying Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) techniques together with Fourier-Transform Infrared spectroscopy (FT-IR) as paired technique to aid in the interpretation of outcome. Chosen excipients were Cross carmellose sodium, microcrystalline cellulose, magnesium stearate, sodium starch glycolate, and pregelatinised starch. Results illustrated that drug was compatible with all the excipients except magnesium stearate where a slight degree of physical interaction was observed but mass loss due to degradation was not hastened in TGA. FT-IR study lined out any chemical change of drug with magnesium stearate. These results would be valuable for formulation development of the film coated tablets of alogliptin benzoate.

Download Full-text

Compatibility Studies of Valsartan with Different Pharmaceutical Excipients

Revista de Chimie ◽

10.37358/rc.19.7.7386 ◽

2019 ◽

Vol 70 (7) ◽

pp. 2590-2600

Author(s):

Ioana Cristina Tita ◽

Lavinia Lupa ◽

Bogdan Tita ◽

Roxana Liana Stan ◽

Laura Vicas

Keyword(s):

Magnesium Stearate ◽

Dosage Forms ◽

Compatibility Studies ◽

Scanning Calorimetry ◽

Pharmaceutical Dosage Forms ◽

Lactose Monohydrate ◽

Pharmaceutical Excipients ◽

Solid Dosage ◽

Fourier Transformed Infrared Spectroscopy ◽

Ft Ir

Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimetry (DSC) were used for a first screening to find small variations in peak temperature and/or their associated enthalpy for six drug/excipient mixtures (starch, cross caramelose sodique, microcrystalline cellulose 102, povidone K30, lactose monohydrate and magnesium stearate), which indicate some degree of interaction. Additional methods using Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) confirmed the incompatibility of VALS with starch, povidone K30, lactose monohydrate and magnesium stearate. Those excipients should be avoided in the development of solid dosage forms.

Download Full-text

Characterization of adsorption behavior by solid dosage form excipients in formulation development

International Journal of Pharmaceutics ◽

10.1016/0378-5173(82)90009-6 ◽

1992 ◽

Vol 83 (1-3) ◽

pp. 65-72 ◽

Cited By ~ 9

Author(s):

Richard I. Senderoff ◽

Majid Mahjour ◽

Galen W. Radebaugh

Keyword(s):

Dosage Form ◽

Adsorption Behavior ◽

Formulation Development ◽

Solid Dosage Form ◽

Solid Dosage

Download Full-text

A comprehensive review on pharmaceutical mini tablets

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i6.2060 ◽

2018 ◽

Vol 8 (6) ◽

pp. 382-390 ◽

Cited By ~ 1

Author(s):

Priyanka Priyanka ◽

Kapil Kumar ◽

Deepak Teotia

Keyword(s):

Dosage Form ◽

Dosage Forms ◽

Oral Dosage ◽

Formulation Development ◽

Coating Materials ◽

Solid Dosage Form ◽

Solid Dosage ◽

Therapeutic Benefits ◽

Form Design ◽

Oral Dosage Forms

Mini-tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less. Offering some therapeutic benefits such as dose flexibility and combined release patterns. They do not require any solvent for their production and also local irritation can be avoided by the use of mini tablet Mini tablet offer several advantages like they can be manufactured relatively easily, They are not require less coating materials and also there is a great flexibility during their formulation development. Mini tablet are more acceptable in children and elderly people as they are easy to swallow. The objective of controlled drug delivery systems is to reduce the frequency of the dosing and to increase the effectiveness of the drug by localization. Keywords: Mini-tablets, solid dosage form, oral dosage forms.

Download Full-text