Relaxant effect of the volatile oil of Romarinus officinalis on tracheal smooth muscle

1991 ◽  
Vol 33 (1-2) ◽  
pp. 57-62 ◽  
Author(s):  
M.B. Aqel
2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Hamideh Kazemi Rad ◽  
Arghavan Memarzia ◽  
Fatemeh Amin ◽  
Mohammad Hossein Boskabady

Urginea maritima (U. maritima) showed anti-inflammatory, antioxidant, antibacterial, diuretic, vasodilatation, and wound-healing effects on fungal infections, cardiac disorders, digestive disorders, rheumatoid disease, and respiratory disorders such as bronchitis, bronchial nosocomial infections, and severe cough. To examine the bronchodilatory effect of U. maritima, the relaxant effect of its extract on rat tracheal smooth muscle (TSM) and its possible mechanism was examined in this study. Male Wistar rats’ TSM were divided into eight groups (n = 8 in each group). Four of these groups were TSM tissues, contracted with KCl (60 mM) incubated with atropine, glibenclamide, and indomethacin and nonincubated TSM, while the other four groups were TSM tissues contracted with methacholine (10 μM) for 5 min, incubated with propranolol, chlorpheniramine, and diltiazem and nonincubated TSM. Cumulative concentrations of U. maritima extract (12.5, 25, 50, 100, 20, and 400 μg/ml) were then added to organ bath every 5 min. Theophylline (0.2, 0.4, 0.6, and 0.8 mM) as positive control and saline (1 ml) as negative control were also examined in nonincubated tissues. A concentration-dependent relaxant effect of U. maritima on nonincubated TSM contracted with KCl (60 mM) or methacholine (10 μM) ( p < 0.01 and p < 0.001 ) was observed. The relaxant effects of U. maritima extract in the incubated tissues with glibenclamide, propranolol, diltiazem, atropine, and chlorpheniramine were significantly lower than those in the nonincubated tissues ( p < 0.05 to p < 0.001 ). EC50 values of U. maritima extract in the incubated TSM with glibenclamide, propranolol, diltiazem, and atropine were significantly higher than those in the nonincubated tissues ( p < 0.05 for diltiazem-incubated tissues and p < 0.001 for other cases). U. maritima extract displayed considerable relaxant effect on TSM comparable to the effect of theophylline. Beta-2 adrenoceptor stimulation and muscarinic receptor inhibition as well as potassium opening and calcium channels blocking effects are the possible mechanisms for the relaxant effects of the plant.


2017 ◽  
Vol 55 (1) ◽  
pp. 2248-2258 ◽  
Author(s):  
Bahman Emami ◽  
Farzaneh Shakeri ◽  
Vahideh Ghorani ◽  
Mohammad Hossein Boskabady

2003 ◽  
Vol 470 (1-2) ◽  
pp. 57-64 ◽  
Author(s):  
Hiroshi Moriuchi ◽  
Tsutomu Nakahara ◽  
Takeshi Maruko ◽  
Kenji Sakamoto ◽  
Kunio Ishii

Planta Medica ◽  
2016 ◽  
Vol 83 (07) ◽  
pp. 624-630 ◽  
Author(s):  
Yi-Lin Zhang ◽  
Jia-Wen Xu ◽  
Xiong-Hao Wu ◽  
Peng-Xiao Chen ◽  
Fang Wei ◽  
...  

1996 ◽  
Vol 76 (2) ◽  
pp. 266-270 ◽  
Author(s):  
K Hirota ◽  
T Sato ◽  
S F Rabito ◽  
E K Zsigmond ◽  
A Matsuki

2013 ◽  
Vol 49 (0) ◽  
pp. 15-25
Author(s):  
Italo R. R. Martins ◽  
Rosimeire F. dos Santos ◽  
Ana C. de C. Correia ◽  
Gislaine A. de Oliveira ◽  
Cib^|^eacute;rio L. Mac^|^ecirc;do ◽  
...  

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