scholarly journals Cryopreservation affects endothelial and smooth muscle function of canine autogenous saphenous vein grafts

1991 ◽  
Vol 13 (5) ◽  
pp. 584-592 ◽  
Author(s):  
James R. Elmore ◽  
Peter Gloviczki ◽  
Kelvin G.M. Brockbank ◽  
Virginia M. Miller
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Muscle Function ◽  
Vein Grafts ◽  
Saphenous Vein Grafts ◽  
Smooth Muscle Function

Cryopreservation affects endothelial and smooth muscle function of canine autogenous saphenous vein grafts

1991 ◽  
Vol 13 (5) ◽  
pp. 584-592 ◽  
Author(s):  
Jonathan B. Towne ◽  
James R. Elmore ◽  
Peter R. Gloviczki ◽  
Kelvin G. M. Brockbank
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Muscle Function ◽  
Vein Grafts ◽  
Saphenous Vein Grafts ◽  
Smooth Muscle Function

N-Acetylcysteine Does Not Improve the Endothelial and Smooth Muscle Function in the Human Saphenous Vein

2007 ◽  
Vol 41 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Muhammad Anees Sharif ◽  
Ulvi Bayraktutan ◽  
Ian Stuart Young ◽  
Chee Voon Soong
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Muscle Function ◽  
Ex Vivo ◽  
Smooth Muscle Relaxation ◽  
Organ Bath ◽  
Human Saphenous Vein ◽  
Vein Segment ◽  
Significant Difference ◽  
Smooth Muscle Function

Oxidative stress can lead to vein graft dysfunction in the saphenous vein. This ex vivo study is aimed to compare the effects of increasing concentrations of the antioxidant N-acetylcysteine (NAC) with heparinized saline (HS) on endothelial and smooth muscle function in the human saphenous vein. Long saphenous vein segment obtained during infrainguinal bypass surgery was divided into 7 rings; 1 immersed in HS and the remaining 6 in increasing NAC concentrations (0.0025%, 0.005%, 0.01%, 0.02%, 0.03%, and 0.04%). Rings were mounted in an organ bath, and relaxant responses to acetylcholine and sodium nitroprusside were assessed through isometric tension studies. Endothelium-dependent relaxations were observed in 77 vein segments from 11 patients. No significant difference was seen in veins treated with either lower NAC concentrations (0.0025%, 0.005%, 0.01%, 0.02%, and 0.03%) or HS. However, HS-treated veins showed significantly better relaxation compared to those treated with maximum (0.04%) NAC ( P < .05). Endothelium-independent relaxations were observed in 91 segments from 13 patients. No difference in relaxation was observed between veins treated with HS or any of the NAC concentrations. In conclusion, lower NAC concentrations do not offer better endothelial protection than HS, whereas the highest NAC concentration has a detrimental effect on endothelium-dependent relaxation. Moreover, NAC did not show beneficial effect on direct smooth muscle relaxation.

Human saphenous vein grafts explanted from the arterial circulation demonstrate altered smooth-muscle and endothelial responses

1993 ◽  
Vol 18 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Thomas C. Park ◽  
Christian T. Harker ◽  
James M. Edwards ◽  
Gregory L. Moneta ◽  
Lloyd M. Taylor ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Human Saphenous Vein ◽  
Vein Grafts ◽  
Arterial Circulation ◽  
Saphenous Vein Grafts

scholarly journals PS206. “Back-Table” Manipulation of Human Saphenous Vein Significantly Impairs Endothelial and Smooth Muscle Function

2011 ◽  
Vol 53 (6) ◽  
pp. 83S
Author(s):  
Michael J. Osgood ◽  
Kyle M. Hocking ◽  
Kevin W. Sexton ◽  
Padmini Komalavilas ◽  
Joyce Cheung-Flynn ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Muscle Function ◽  
Human Saphenous Vein ◽  
Smooth Muscle Function

Minimally invasive saphenous vein harvesting: effects on endothelial and smooth muscle function

2001 ◽  
Vol 71 (5) ◽  
pp. 1503-1507 ◽  
Author(s):  
Edward A. Black ◽  
Tomasz J. Guzik ◽  
Nick E.J. West ◽  
Karen Campbell ◽  
Ravi Pillai ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Minimally Invasive ◽  
Saphenous Vein ◽  
Muscle Function ◽  
Smooth Muscle Function ◽  
Vein Harvesting

Accelerated smooth muscle cell apoptosis in occluded aorto-coronary saphenous vein grafts

2011 ◽  
Vol 10 (04) ◽  
pp. 237-240
Author(s):  
Claus Bartels ◽  
Rainer Malisius ◽  
Friedhelm Sayk ◽  
Matthias Bechtel ◽  
Rainer Leyh ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Saphenous Vein ◽  
Cell Apoptosis ◽  
Vein Grafts ◽  
Saphenous Vein Grafts ◽  
Muscle Cell Apoptosis

Accelerated Smooth Muscle Cell Apoptosis in Occluded Aorto-coronary Saphenous Vein Grafts

2001 ◽  
Vol 10 (4) ◽  
pp. 237-240
Author(s):  
Friedhelm Sayk ◽  
J.F. Matthias Bechtel ◽  
Alfred C. Feller ◽  
Hans-Hinrich Sievers ◽  
Claus Bartels ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Saphenous Vein ◽  
Cell Apoptosis ◽  
Vein Grafts ◽  
Saphenous Vein Grafts ◽  
Muscle Cell Apoptosis

The modulation of smooth muscle cell phenotype is an early event in human aorto-coronary saphenous vein grafts

1992 ◽  
Vol 420 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Mark M. Kockx ◽  
Bernard A. Cambier ◽  
Hilde E. Bortier ◽  
Guido R. Meyer ◽  
Philip A. Cauwelaert
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Saphenous Vein ◽  
Cell Phenotype ◽  
Early Event ◽  
Vein Grafts ◽  
Saphenous Vein Grafts ◽  
Smooth Muscle Cell Phenotype

Immunohistochemical and Ultrastructural Examination of Smooth Muscle Cells in Aortocoronary Saphenous Vein Grafts

Angiology ◽  
1997 ◽  
Vol 48 (5) ◽  
pp. 381-390 ◽  
Author(s):  
Takahiro Yamada ◽  
Ryo Shiraishi ◽  
Kenji Taki ◽  
Shigeo Nakano ◽  
Osamu Tokunaga ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Saphenous Vein ◽  
Muscle Cells ◽  
Ultrastructural Examination ◽  
Vein Grafts ◽  
Saphenous Vein Grafts
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