In vitro and in vivo D2-dopamine receptor binding with [123I]S(−)iodobenzamide ([123I]IBZM) in rat and human brain

1991 ◽  
Vol 18 (8) ◽  
pp. 837-846 ◽  
Author(s):  
N.P.L.G. Verhoeff ◽  
M. Bobeldijk ◽  
M.G.P. Feenstra ◽  
G.J. Boer ◽  
M.A.W. Maas ◽  
...  
Keyword(s):  
Human Brain ◽  
Dopamine Receptor ◽  
Receptor Binding ◽  
D2 Dopamine Receptor ◽  
Dopamine Receptor Binding

Characterization of the radioiodinated analogue of SCH 23390: In vitro and in vivo D-1 dopamine receptor binding studies

Life Sciences ◽  
1988 ◽  
Vol 43 (14) ◽  
pp. 1151-1160 ◽  
Author(s):  
Robert D. McQuade ◽  
Richard Chipkin ◽  
Nordine Amlaiky ◽  
Marc Caron ◽  
Louis Iorio ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Binding ◽  
Sch 23390 ◽  
Binding Studies ◽  
Dopamine Receptor Binding

Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence

1994 ◽  
Vol 116 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Jarmo Hietala ◽  
Curt West ◽  
Erkka Syvälahti ◽  
Kjell Någren ◽  
Pertti Lehikoinen ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Receptor Binding ◽  
D2 Dopamine Receptor ◽  
Binding Characteristics ◽  
Dopamine Receptor Binding

Effects of rolipram on in vivo dopamine receptor binding

2002 ◽  
Vol 109 (9) ◽  
pp. 1139-1149 ◽  
Author(s):  
R. Hosoi ◽  
M. Ishikawa ◽  
K. Kobayashi ◽  
A. Gee ◽  
M. Yamaguchi ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Binding ◽  
Dopamine Receptor Binding

scholarly journals Quantification of Neuroreceptors in the Living Human Brain: III. D2-Like Dopamine Receptors: Theory, Validation, and Changes during Normal Aging

1997 ◽  
Vol 17 (3) ◽  
pp. 316-330 ◽  
Author(s):  
Dean F. Wong ◽  
David Young ◽  
P. David Wilson ◽  
Carolyn Cidis Meltzer ◽  
Albert Gjedde
Keyword(s):  
Human Brain ◽  
Dopamine Receptor ◽  
Normal Aging ◽  
Receptor Density ◽  
Least Squares Regression ◽  
Noise Levels ◽  
Normal Humans ◽  
Statistical Noise

Dopamine receptor density is believed to decline in normal aging. To test this hypothesis, we measured the density of dopamine D2-like receptors in vivo in the neostriatum of normal living humans by using the graphical method. This method determines the D2-like dopamine receptor density in the human brain with an occupying ligand (unlabeled haloperidol) and a radioligand (labeled 3- N-methylspiperone). The method was examined critically, and the assumptions underlying the method were shown to be valid. The validation included comparison of the representation of tracer metabolism by high-pressure liquid chromatography and model assays, calculation of the lumped constant Dw from the value of its components, and comparable tracer partition coefficients in vitro and in vivo. In error analysis, the method consistently performed as well as the direct least-squares regression at statistical noise levels appropriate for the tomograph used in these studies. The method revealed that the density of the D2-like receptors that bind haloperidol in the caudate nucleus of normal humans declined 1% per year after the age of 18 years.

In vivo dopamine receptor binding studies with a non-radioactively labeled agonist, dipropyl-5, 6-ADTN

Life Sciences ◽  
1983 ◽  
Vol 32 (12) ◽  
pp. 1313-1323 ◽  
Author(s):  
Matthijs G.P. Feenstra ◽  
Hans Rollema ◽  
Theo B.A. Mulder ◽  
Ben H.C. Westerink ◽  
Alan S. Horn
Keyword(s):  
Dopamine Receptor ◽  
Receptor Binding ◽  
Binding Studies ◽  
Dopamine Receptor Binding
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