Assignment of the interleukin-2 receptor β chain gene (II-2rb) to band E on mouse chromosome 15

Genomics ◽  
1992 ◽  
Vol 12 (1) ◽  
pp. 179-180 ◽  
Author(s):  
Hugh D. Campbell ◽  
Graham C. Webb ◽  
Takeshi Kono ◽  
Tadatsugu Taniguchi ◽  
Judith H. Ford ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Chromosome 15 ◽  
Interleukin 2 Receptor ◽  
Β Chain

Transcriptional regulation of the mouse interleukin-2 receptor β chain gene by Ets and Egr-1

2005 ◽  
Vol 329 (3) ◽  
pp. 1094-1101 ◽  
Author(s):  
Sang-Kyu Ye ◽  
Tack Joong Kim ◽  
Sung Sik Won ◽  
Taek Joon Yoon ◽  
Tae Kyu Park ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Interleukin 2 Receptor ◽  
Β Chain

scholarly journals The human interleukin-2 receptor β-chain gene: genomic organization, promoter analysis and chromosomal assignment

1990 ◽  
Vol 18 (13) ◽  
pp. 3697-3703 ◽  
Author(s):  
Hiroshi Shibuya ◽  
Mitsutoshi Yoneyama ◽  
Yusuke Nakamura ◽  
Hisashi Harada ◽  
Masanori Hatakeyama ◽  
...  
Keyword(s):  
Promoter Analysis ◽  
Genomic Organization ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Chromosomal Assignment ◽  
Interleukin 2 Receptor ◽  
Β Chain

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

Science ◽  
1989 ◽  
Vol 244 (4904) ◽  
pp. 551-556 ◽  
Author(s):  
M Hatakeyama ◽  
M Tsudo ◽  
S Minamoto ◽  
T Kono ◽  
T Doi ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Chain Gene ◽  
Beta Chain ◽  
Interleukin 2 Receptor ◽  
Receptor Beta

scholarly journals Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.

1993 ◽  
Vol 13 (10) ◽  
pp. 6201-6210 ◽  
Author(s):  
J X Lin ◽  
N K Bhat ◽  
S John ◽  
W S Queale ◽  
W J Leonard
Keyword(s):  
Binding Site ◽  
Phorbol Myristate Acetate ◽  
Promoter Activity ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Beta Chain ◽  
Myristate Acetate ◽  
Interleukin 2 Receptor ◽  
Mg63 Cells ◽  
Beta Gene

The interleukin-2 receptor (IL-2R) beta chain (IL-2R beta) is an essential signaling component of high- and intermediate-affinity IL-2Rs. Our laboratory previously reported that a DNA fragment containing 857 bp of 5'-flanking sequence of the human IL-2R beta gene exhibited promoter activity. We have now further characterized the promoter and delineated cis-acting regulatory regions. The region downstream of -363 is critical for basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and contains at least three enhancer-like regions. Among them, the -56 to -34 enhancer was the most potent and had high-level activity in two T-cell lines but not in nonlymphoid HeLaS3 and MG63 cells. This enhancer contains a GGAA Ets binding site which bound two Ets family proteins, Ets-1 and GA-binding protein in vitro. Mutation of the Ets motif strongly diminished both promoter and enhancer activities. We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene.

scholarly journals Interleukin-2 Receptor β-Chain (p70-75) Expressed on Leukemic Cells from Adult T Cell Leukemia Patients

1990 ◽  
Vol 81 (9) ◽  
pp. 902-908 ◽  
Author(s):  
Taiichi Kodaka ◽  
Takashi Uchiyama ◽  
Takayuki Ishikawa ◽  
Masanori Kamio ◽  
Rie Onishi ◽  
...  
Keyword(s):  
T Cell ◽  
Interleukin 2 ◽  
Leukemic Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Β Chain

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

2014 ◽  
Vol 337 (1-2) ◽  
pp. 147-150 ◽  
Author(s):  
Gulibahaer Ainiding ◽  
Yuji Kawano ◽  
Shinya Sato ◽  
Noriko Isobe ◽  
Takuya Matsushita ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neuromyelitis Optica ◽  
Gene Polymorphisms ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Interleukin 2 Receptor ◽  
Α Chain

scholarly journals Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.

1990 ◽  
Vol 10 (2) ◽  
pp. 850-853 ◽  
Author(s):  
B B Lin ◽  
S L Cross ◽  
N F Halden ◽  
D G Roman ◽  
M B Toledano ◽  
...  
Keyword(s):  
Regulatory Element ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Enhancer Activity ◽  
Enhancer Element ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Interleukin 2 Receptor ◽  
Positive Regulatory Element ◽  
Receptor Alpha Chain

We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation. This enhancerlike element contains a site (-268/-257) that can bind NF-kappa B; however, unlike the immunoglobulin kappa gene kappa B enhancer element, the IL-2R alpha kappa B-like site alone can only weakly activate a heterologous promoter. Adjacent 5' and 3' sequences also weakly activate the tk-CAT vector, but constructs combining the IL-2R alpha kappa B-like site plus adjacent 5' and 3' sequences potently activate gene expression. This combination of regions is essential for potent PMA-induced transcription from the tk promoter. Experiments using constructs in which IL-2R alpha upstream sequences are sequentially deleted suggested that there is a region 5' of position -299 which can suppress IL-2R alpha promoter and/or enhancer activity. Thus, it is possible that both positive and negative elements may be important in the regulation of IL-2R alpha gene transcription.

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