Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

Neuron ◽  
1993 ◽  
Vol 10 (3) ◽  
pp. 359-367 ◽  
Author(s):  
Vassilis E. Koliatsos ◽  
Richard E. Clatterbuck ◽  
John W. Winslow ◽  
Michelle H. Cayouette ◽  
Donald L. Prices
Keyword(s):  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Trophic Factor

Developmental programmes of growth and survival in early sensory neurons

1991 ◽  
Vol 331 (1261) ◽  
pp. 259-262
Keyword(s):  
Nervous System ◽  
Sensory Neurons ◽  
Neurotrophic Factor ◽  
Target Distance ◽  
Trophic Factor ◽  
Growth And Survival ◽  
Target Field ◽  
Developing Nervous System

In the developing vertebrate nervous system the survival of neurons becomes dependent on the supply of a neurotrophic factor from their targets when their axons reach these targets. To determine how the onset of neurotrophic factor dependency is coordinated with the arrival of axons in the target field, we have studied the growth and survival of four populations of cranial sensory neurons whose axons have markedly different distances to grow to reach their targets. Axonal growth rate both in vivo and in vitro is related to target distance; neurons with more distant targets grow faster. The onset trophic factor dependency in culture is also related to target distance; neurons with more distant targets survive longer before becoming trophic factor dependent. These data suggest that programmes of growth and survival in early neurons play an important role in coordinating the timing of trophic interactions in the developing nervous system.

scholarly journals Interferon beta-1a induces expression of brain-derived neurotrophic factor in human T lymphocytes in vitro and not in vivo

2020 ◽  
Vol 15 (1) ◽  
pp. FNL38 ◽  
Author(s):  
Zarlascht Karmand ◽  
Hans-Peter Hartung ◽  
Oliver Neuhaus
Keyword(s):  
T Cell ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Peripheral Blood Lymphocytes ◽  
T Cell Proliferation ◽  
Bdnf Expression ◽  
Healthy Donors

Aim: To detect IFN β-1a-induced expression of brain-derived neurotrophic factor (BDNF) to undermine the hypothesis of IFN β-1a-associated neuroprotection in multiple sclerosis (MS). Methods: The influence of IFN β-1a on in vitro activated peripheral blood lymphocytes from healthy donors was tested. Proliferation analyses were made to detect T-cell growth. BDNF expression was measured by standard ELISA. To assess the influence of IFN β-1a on BDNF expression in vivo, BDNF serum levels of MS patients treated with IFN β-1a were compared with those of untreated patients. Results: IFN β-1a inhibited T-cell proliferation dose dependently. It induced BDNF expression at middle concentrations. MS patients treated with IFN β-1a exhibited significantly lower BDNF serum levels than untreated patients. Conclusion: IFN β-1a may promote neuroprotection by inducing BDNF expression, but its importance in vivo remains open.

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

Nature ◽  
1992 ◽  
Vol 360 (6406) ◽  
pp. 753-755 ◽  
Author(s):  
Qiao Yan ◽  
Jeffrey Elliott ◽  
William D. Snider
Keyword(s):  
Cell Death ◽  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Spinal Motor Neurons ◽  
Spinal Motor

scholarly journals Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor (BDNF) in the striatum

FEBS Letters ◽  
1992 ◽  
Vol 313 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Hitoshi Okazawa ◽  
Miho Murata ◽  
Masahiko Watanabe ◽  
Masaki Kamei ◽  
Ichiro Kanazawa
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
In Vivo Expression ◽  
Dopaminergic Stimulation
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