Effect of microinjection of glucose into the hypothalamic nucleus on efferent activity of the pancreatic branch of the vagus nerve in the rat

1988 ◽  
Vol 7 ◽  
pp. S40
Author(s):  
Akira Niijima ◽  
Hiroshi Kannan ◽  
Hiroshi Yamashita
Keyword(s):  
Vagus Nerve ◽  
Hypothalamic Nucleus ◽  
Efferent Activity

Studies of the Central Neural Pathways to the Stomach and Zusanli (ST36)

2001 ◽  
Vol 29 (02) ◽  
pp. 211-220 ◽  
Author(s):  
Chang Hyun Lee ◽  
Han Sol Jung ◽  
Tae Young Lee ◽  
Sang Ryoung Lee ◽  
Sang Won Yuk ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vagus Nerve ◽  
Nucleus Tractus Solitarius ◽  
Area Postrema ◽  
Reticular Nucleus ◽  
Hypothalamic Nucleus ◽  
Cell Group ◽  
Motor Nucleus ◽  
Amygdaloid Nucleus ◽  
Dorsal Motor Nucleus

The purpose of this morphological study was to investigate the relation between the meridian, meridian points and viscera using neuroanatomical tracers. The common locations of the spinal cord and brain projecting to the stomach and Zusanli were observed following injection of CTB (cholera toxin B subunit) and pseudorabies viruses (PRV-Ba, Bartha strain and PRV-Ba-Gal, galactosidase insertion) into the stomach and Zusanli (ST36). After 4–5 days of survival following injection into twelve rats, they were perfused, and their spinal cords and brains were frozen sectioned (30 μm). These sections were stained by X-gal histochemical, CTB and PRV-Bia immunohistochemical staining methods, and examined with the light microscope. The results were as follows: Commonly labeled medulla oblongata regions were dorsal motor nucleus of vagus nerve (DMV), nucleus tractus solitarius (NTS) and area postrema (AP) following injection of CTB and PRV-Ba-Gal into stomach and Zusanli, respectively. In the spinal cord, commonly labeled neurons were found in thoracic, lumbar and sacral spinal segments. Densely labeled areas were found in lamina IV, V, VII (intermediolateral nucleus) and X of the spinal cord. In the brain, commonly labeled neurons were found in the A1 noradrenalin cells/C1 adrenalin cells/caudoventrolateral reticular nucleus, dorsal motor nucleus of vagus nerve, nucleus tractus solitarius, area postrema, raphe obscurus nucleus, raphe pallidus nucleus, raphe magnus nucleus, gigantocellular nucleus, locus coeruleus, parabrachial nucleus, Kolliker-Fuse nucleus, A5 cell group, central gray matter, paraventricular hypothalamic nucleus, lateral hypothalamic nucleus, retrochiasmatic hypothalamic nucleus, bed nucleus of stria terminals and amygdaloid nucleus. Thus central autonomic center project both to the stomach and Zusanli. These morphological results suggest that there is a commonality of CNS cell groups in brain controlling stomach (viscera) and Zusanli (limb).

684 Vagus Nerve Efferent Activity Enhances Bacterial Uptake and Potentiates TGF-Beta Signaling in Intestinal Lamina Propria Macrophages

2009 ◽  
Vol 136 (5) ◽  
pp. A-106-A-107
Author(s):  
Wouter de Jonge ◽  
Caroline Verseyden ◽  
Susanne A. Snoek ◽  
Kevin Lee ◽  
Rene M. van den Wijngaard ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Lamina Propria ◽  
Tgf Beta ◽  
Intestinal Lamina Propria ◽  
Efferent Activity ◽  
Bacterial Uptake

Effect of oral administration of Pinellia ternata, Zingiberis rhizoma and their mixture on the efferent activity of the gastric branch of the vagus nerve in the rat

1998 ◽  
Vol 258 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Akira Niijima ◽  
Masayoshi Kubo ◽  
Kazunori Hashimoto ◽  
Yasuhiro Komatsu ◽  
Masao Maruno ◽  
...  
Keyword(s):  
Oral Administration ◽  
Vagus Nerve ◽  
Pinellia Ternata ◽  
Efferent Activity

scholarly journals Melanocortin 4 Receptor Activation Protects Against Testicular Ischemia-Reperfusion Injury by Triggering the Cholinergic Antiinflammatory Pathway

Endocrinology ◽  
2011 ◽  
Vol 152 (10) ◽  
pp. 3852-3861 ◽  
Author(s):  
Letteria Minutoli ◽  
Alessandra Bitto ◽  
Francesco Squadrito ◽  
Natasha Irrera ◽  
Mariagrazia Rinaldi ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Receptor Antagonist ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Organ Damage ◽  
Receptor Activation ◽  
Male Rats ◽  
Efferent Activity ◽  
Tnf Α ◽  
Testicular Ischemia

Melanocortins (MC) trigger a vagus nerve-mediated cholinergic-antiinflammatory pathway projecting to the testis. We tested whether pharmacological activation of brain MC receptors might protect the testis from the damage induced by ischemia-reperfusion. Adult male rats were subjected to 1-h testicular ischemia, followed by 24-h reperfusion [testicular ischemia-reperfusion (TI/R)]. Before TI/R, groups of animals were subjected to bilateral cervical vagotomy, or pretreated with the nicotinic acetylcholine receptor antagonist chlorisondamine or the selective MC4 receptor antagonist HS024. Immediately after reperfusion, rats were ip treated with saline or the MC analog [Nle4,D-Phe7]α-melanocyte-stimulating hormone (NDP-α-MSH) (340 μg/kg). We evaluated testicular IL-6 and TNF-α by Western blot analysis and organ damage by light microscopy. Some experimental groups were prepared for neural efferent activity recording along the vagus nerve starting 30 min after treatment with NDP-α-MSH or saline, and for a 30-min period. Additional groups of TI/R rats were treated for 30 d with saline, NDP-α-MSH, chlorisondamine plus NDP-α-MSH, or HS024 plus NDP-α-MSH to evaluate spermatogenesis, organ damage, and the apoptosis machinery. After a 24-h reperfusion, in TI/R saline-treated rats, there was an increase in IL-6 and TNF-α expression and a marked damage in both testes. NDP-α-MSH inhibited IL-6 and TNF-α expression, decreased histological damage, and increased neural efferent activity. Furthermore, NDP-α-MSH administration for 30 d greatly improved spermatogenesis, reduced organ damage, and inhibited apoptosis. All positive NDP-α-MSH effects were abrogated by vagotomy, chlorisondamine, or HS024. Our data suggest that selective MC4 receptor agonists might be therapeutic candidates for the management of testicular torsion.

The effect of interleukin-1β on the efferent activity of the vagus nerve to the thymus

1995 ◽  
Vol 54 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Akira Niijima ◽  
Tetsuro Hori ◽  
Toshihiko Katafuchi ◽  
Tomoyasu Ichijo
Keyword(s):  
Vagus Nerve ◽  
Interleukin 1Β ◽  
Efferent Activity
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