A single-base-pair substitution abolishes d-amino-acid oxidase activity in the mouse

1992 ◽  
Vol 1139 (4) ◽  
pp. 315-318 ◽  
Author(s):  
Masato Sasaki ◽  
Ryuichi Konno ◽  
Masahiro Nihio ◽  
Akira Niwa ◽  
Yosihiro Yasumura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Base Pair ◽  
Oxidase Activity ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Single Base ◽  
Single Base Pair Substitution ◽  
Single Base Pair ◽  
Base Pair Substitution

scholarly journals Systematic single base-pair substitution analysis of DNA binding by the cAMP receptor protein in cyanobacteriumSynechocystissp. PCC 6803

FEBS Letters ◽  
2004 ◽  
Vol 563 (1-3) ◽  
pp. 55-58 ◽  
Author(s):  
Katsumi Omagari ◽  
Hidehisa Yoshimura ◽  
Mitsunori Takano ◽  
Dongyun Hao ◽  
Masayuki Ohmori ◽  
...  
Keyword(s):  
Dna Binding ◽  
Base Pair ◽  
Receptor Protein ◽  
Camp Receptor Protein ◽  
Single Base ◽  
Single Base Pair Substitution ◽  
Single Base Pair ◽  
Base Pair Substitution ◽  
Camp Receptor ◽  
Pcc 6803

A single base pair substitution within the paired box of PAX3 in an individual with Waardenburg syndrome type 1 (WS1)

1994 ◽  
Vol 4 (3) ◽  
pp. 227-228 ◽  
Author(s):  
John W. Pierpont ◽  
Luke D. Doolan ◽  
Kurt Amann ◽  
Greg R. Snead ◽  
Robert P. Erickson
Keyword(s):  
Base Pair ◽  
Syndrome Type ◽  
Waardenburg Syndrome ◽  
Single Base ◽  
Single Base Pair Substitution ◽  
Single Base Pair ◽  
Base Pair Substitution

Impairment of Platelet Aggregation by Echis colorata Venom Mediated by L-Amino Acid Oxidase or H2O2

1982 ◽  
Vol 48 (03) ◽  
pp. 277-282 ◽  
Author(s):  
I Nathan ◽  
A Dvilansky ◽  
T Yirmiyahu ◽  
M Aharon ◽  
A Livne
Keyword(s):  
Hydrogen Peroxide ◽  
Amino Acid ◽  
Platelet Aggregation ◽  
Snake Venom ◽  
Oxidase Activity ◽  
Enzyme Preparation ◽  
Acid Oxidase ◽  
Crude Venom ◽  
Amino Acid Oxidase ◽  
Hemostatic Disorders

SummaryEchis colorata bites cause impairment of platelet aggregation and hemostatic disorders. The mechanism by which the snake venom inhibits platelet aggregation was studied. Upon fractionation, aggregation impairment activity and L-amino acid oxidase activity were similarly separated from the crude venom, unlike other venom enzymes. Preparations of L-amino acid oxidase from E.colorata and from Crotalus adamanteus replaced effectively the crude E.colorata venom in impairment of platelet aggregation. Furthermore, different treatments known to inhibit L-amino acid oxidase reduced in parallel the oxidase activity and the impairment potency of both the venom and the enzyme preparation. H2O2 mimicked characteristically the impairment effects of L-amino acid oxidase and the venom. Catalase completely abolished the impairment effects of the enzyme and the venom. It is concluded that hydrogen peroxide formed by the venom L-amino acid oxidase plays a role in affecting platelet aggregation and thus could contribute to the extended bleeding typical to persons bitten by E.colorata.

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