Tissue-based in vitro and ex vivo models for vaginal permeability studies

2016 ◽  
pp. 273-308 ◽  
Author(s):  
Alexandra Machado ◽  
José das Neves
Keyword(s):  
Ex Vivo ◽  
Permeability Studies

In Vitro and Ex Vivo Permeability Studies of Paclitaxel and Doxorubicin From Drug-Eluting Biodegradable Ureteral Stents

2017 ◽  
Vol 106 (6) ◽  
pp. 1466-1474 ◽  
Author(s):  
Alexandre A. Barros ◽  
Carlos Oliveira ◽  
Rui L. Reis ◽  
Estevão Lima ◽  
Ana Rita C. Duarte
Keyword(s):  
Ex Vivo ◽  
Ureteral Stents ◽  
Drug Eluting ◽  
Permeability Studies

scholarly journals Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil Transdermal Patches

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 205
Author(s):  
Linh Dinh ◽  
Soohun Lee ◽  
Sharif Md Abuzar ◽  
Heejun Park ◽  
Sung-Joo Hwang
Keyword(s):  
Ionic Liquid ◽  
Ex Vivo ◽  
Optical Microscope ◽  
Skin Permeability ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry ◽  
Ionic Bonds ◽  
Gastrointestinal Side Effects ◽  
Permeability Studies

Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic bonds were created by dissolving dicarboxylic acid and DPZ in ethanol, resulting in a stable ionic liquid (IL) state. The synthesized ILs were characterized by differential scanning calorimetry, optical microscope, Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. The DPZ ILs were then transformed to a suitable drug-in-adhesive patch for transdermal delivery of DPZ. The novel DPZ ILs patch inhibits crystallization of the IL, indicating coherent design. Moreover, DPZ ILs and DPZ IL patch formulations performed excellent skin permeability compared to that of the DPZ free-base patch in both in vitro and ex vivo skin permeability studies.

Tissue-based in vitro and ex vivo models for buccal permeability studies

2016 ◽  
pp. 189-202 ◽  
Author(s):  
Pedro Castro ◽  
Raquel Madureira ◽  
Bruno Sarmento ◽  
Manuela Pintado
Keyword(s):  
Ex Vivo ◽  
Permeability Studies

scholarly journals Microflow-Based Device for In Vitro and Ex Vivo Drug Permeability Studies

2020 ◽  
Vol 25 (5) ◽  
pp. 455-462
Author(s):  
Samu Hemmilä ◽  
Marika Ruponen ◽  
Elisa Toropainen ◽  
Unni Tengvall-Unadike ◽  
Arto Urtti ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Ussing Chamber ◽  
Cell Models ◽  
Excellent Correlation ◽  
Apparent Permeability ◽  
Drug Permeability ◽  
Test Conditions ◽  
Permeability Studies ◽  
Ex Vivo Tissues

This paper presents a novel microflow-based concept for studying the permeability of in vitro cell models or ex vivo tissues. Using the proposed concept, we demonstrate how to maintain physiologically relevant test conditions and produce highly reproducible permeability values for a range (31) of drug compounds. The apparent permeability coefficients ( Papp) showed excellent correlation (0.89) with the values from experiments performed with a conventional Ussing chamber. Additionally, the microflow-based concept produces notably more concentrated samples than the conventional Ussing chamber-based approach, despite the fact that more than 10 times smaller quantities of test compounds and biological membranes are needed in the microflow-based concept.

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