DETECTION OF RADIATION-INDUCED SINGLE-STRAND BREAKS AND BASE DAMAGE IN DNA OF HUMAN WHITE BLOOD CELLS IN FULL BLOOD AFTER IN VITRO AND IN VIVO EXPOSURE

1991 ◽  
pp. 325
Author(s):  
G.P. Van Der Schans ◽  
A.A.W.M. Van Loon ◽  
A.J. Timmerman ◽  
F.J.A. Kouwenberg ◽  
R.H. Groenendijk ◽  
...  
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Single Strand ◽  
Base Damage ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Radiation Induced ◽  
Human White Blood Cells

Compounds of the Cysteine-cysteamine Group and their Influence on Infectivity, Strand Breaks and Base Damage in Gamma-irradiated DNA of Coliphage ΦX-174

1973 ◽  
Vol 28 (7-8) ◽  
pp. 466-470 ◽  
Author(s):  
Günther Stephan ◽  
Gerhart Hotz
Keyword(s):  
Protective Effect ◽  
Sucrose Gradient ◽  
Base Damage ◽  
Rf System ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Radiation Induced ◽  
Gamma Irradiated

Single- and double-stranded (RF) DNA of page ΦX-174 were 60Co-gamma irradiated. Dependence of radiosensitivity on the concentration of cysteamine and cystamine was measured. Radioresistance of DNA in vivo (phage particles) as well as of DNA in vitro (infectious DNA) increase between 10-4 and 10-1 ᴍ of superprotective agents. The same relationship is observed when the DNA is in the dry and in the wet state. By fractionating radiation damaged RFI and radiation induced RFII by means of sucrose gradient sedimentation it was possible to measure the protective effect of cysteamine on lesions other than strand-breaks. A pronounced radioprotective effect of cysteamine on the production of single-strand breaks in RF -DNA was found (DRF 20). The convenience of the RF system for studying effects of radioprotective agents on the occurrence of different radiation induced lesions is discussed.

Chemical Nature of Radiation-Induced Single-Strand Breaks in the DNA of Dormant Barley Seeds in Vivo

1973 ◽  
Vol 55 (2) ◽  
pp. 324 ◽  
Author(s):  
Ahmed El-Metainy ◽  
Shigemitsu Tano ◽  
Keiji Yano ◽  
Hikoyuki Yamaguchi
Keyword(s):  
Chemical Nature ◽  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Radiation Induced

Genotoxic effects in human white blood cells following styrene (in vivo) and styrene oxide (in vitro) exposure

1998 ◽  
Vol 95 ◽  
pp. 41
Author(s):  
B. Marczynski ◽  
M. Peel ◽  
P. Rozynek ◽  
J. Elliehausen ◽  
M. Korn ◽  
...  
Keyword(s):  
Blood Cells ◽  
Styrene Oxide ◽  
White Blood Cells ◽  
Genotoxic Effects ◽  
In Vitro Exposure ◽  
Human White Blood Cells

Detection of Single-strand Breaks and Base Damage in DNA of Blood Cells from Leukaemia Patients Receiving Chemo- and Radiotherapy

1992 ◽  
Vol 62 (1) ◽  
pp. 33-43 ◽  
Author(s):  
A.A.W.M. van Loon ◽  
F.C. Raadsheer ◽  
A.J. Timmerman ◽  
C. Haanen ◽  
J. Wessels ◽  
...  
Keyword(s):  
Blood Cells ◽  
Single Strand ◽  
Base Damage ◽  
Strand Breaks ◽  
Single Strand Breaks
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