Risks and benefits in clinical research

Author(s):  
Evan G. DeRenzo ◽  
Eric A. Singer ◽  
Joel Moss
Author(s):  
Linda A. Parker

In the final chapter, areas of future research in gaining a better understanding the functions of the endocannabinoid system and the effects of cannabis on this system are envisioned. It is critical to investigate the effects produced by various strains of marijuana with different ratios of THC:CBD and other cannabinoids. As well, little is understood about the interaction between marijuana and other drugs, in particular alcohol. Cannabinoid designer drugs, for example Spice, are discussed. Some of the difficulties in conducting valid and reliable human clinical research with marijuana are discussed. A special case is made for palliative care. Finally, risks and benefits of marijuana use for both medicinal and recreational purposes are discussed.


2017 ◽  
Vol 31 (5) ◽  
pp. 446-451 ◽  
Author(s):  
Ahmet Y. Muslumanoglu ◽  
Sven Fuglsig ◽  
Antonio Frattini ◽  
Gaston Labate ◽  
Robert B. Nadler ◽  
...  

Author(s):  
Patrick A. Flume ◽  
Elie F. Berbari ◽  
Laura Viera ◽  
Rachel Hess ◽  
Janine Higgins ◽  
...  

Clinical Risk ◽  
2008 ◽  
Vol 14 (6) ◽  
pp. 215-217 ◽  
Author(s):  
James Appleyard

Children are put at unnecessary risk in everyday clinical practice by being given medicines whose safety and efficacy have not been adequately researched. The lack of appropriate dosage forms for many ‘essential medicines’ for the main five treatable conditions causing the deaths of 10 million children worldwide under the age of 5 years are a major reason why countries are not achieving their millennium developmental goals. There has been understandable reluctance to undertake the necessary research on children. The reasons for this are reviewed. The existing levels of protection for child subjects worldwide are insufficient. Key principles are suggested both to encourage clinical research and to ensure adequate protection for children around the world.


2010 ◽  
Vol 15 (5) ◽  
pp. 487-501 ◽  
Author(s):  
Alan R. Tait ◽  
Terri Voepel-Lewis ◽  
Brian J. Zikmund-Fisher ◽  
Angela Fagerlin

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