Tachykinin Receptor Agents

Author(s):  
Mark A. Simmons
Keyword(s):  
1992 ◽  
Vol 267 (2) ◽  
pp. 1298-1302
Author(s):  
D Monnier ◽  
J F Colas ◽  
P Rosay ◽  
R Hen ◽  
E Borrelli ◽  
...  

Peptides ◽  
1992 ◽  
Vol 13 (2) ◽  
pp. 383-388 ◽  
Author(s):  
François Petitet ◽  
Monique Saffroy ◽  
Yvette Torrens ◽  
Solange Lavielle ◽  
Gérard Chassaing ◽  
...  

1993 ◽  
Vol 11 (1) ◽  
pp. 1-7 ◽  
Author(s):  
I M Adcock ◽  
M Peters ◽  
C Gelder ◽  
H Shirasaki ◽  
C R Brown ◽  
...  

ABSTRACT Substance P has several inflammatory effects on the airways mediated via neurokinin 1 receptors (NK1Rs) and, if released from sensory nerves, may amplify the chronic inflammation seen in asthma. Northern blot analysis of NK1R mRNA in lung showed a 52 ± 10% (s.e.m.; P<0·01) increase in mRNA in the asthmatic lung compared with non-asthmatic control tissue. NK1R mRNA was reduced by 84·5 ± 1·9% after incubation with dexamethasone (1 μm) for 3 h (P<0·01). In contrast, NK2R mRNA was unaltered in asthmatic lungs and dexamethasone treatment had no effect on the level of NK2R mRNA. These results suggest that chronic inflammation in asthma may result in increased NK1R gene expression and that this effect is reversed by glucocorticosteroids.


1993 ◽  
Vol 232 (2-3) ◽  
pp. 255-261 ◽  
Author(s):  
Pierre Picard ◽  
Sylvie Boucher ◽  
Domenico Regoli ◽  
Bruce D. Gitter ◽  
Jeffrey J. Howbert ◽  
...  

2008 ◽  
Vol 32 (6) ◽  
pp. 1023-1030 ◽  
Author(s):  
Tatiana Foroud ◽  
Leah Flury Wetherill ◽  
John Kramer ◽  
Jay A. Tischfield ◽  
John I. Nurnberger ◽  
...  

1987 ◽  
pp. 328-330 ◽  
Author(s):  
M. Wienrich ◽  
I. Lues ◽  
B. E. B. Sandberg ◽  
J. Harting

1992 ◽  
Vol 224 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Hiroshi Morimoto ◽  
Masakatsu Yamashita ◽  
Atsushi Matsuoa ◽  
Hiroshi Miyake ◽  
Takashi Fujii

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