Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids

1993 ◽  
Vol 11 (1) ◽  
pp. 1-7 ◽  
Author(s):  
I M Adcock ◽  
M Peters ◽  
C Gelder ◽  
H Shirasaki ◽  
C R Brown ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Inflammation ◽  
Northern Blot Analysis ◽  
Receptor Gene ◽  
Sensory Nerves ◽  
R Gene ◽  
Dexamethasone Treatment ◽  
Tachykinin Receptor ◽  
Neurokinin 1 ◽  
Receptor Gene Expression

ABSTRACT Substance P has several inflammatory effects on the airways mediated via neurokinin 1 receptors (NK1Rs) and, if released from sensory nerves, may amplify the chronic inflammation seen in asthma. Northern blot analysis of NK1R mRNA in lung showed a 52 ± 10% (s.e.m.; P<0·01) increase in mRNA in the asthmatic lung compared with non-asthmatic control tissue. NK1R mRNA was reduced by 84·5 ± 1·9% after incubation with dexamethasone (1 μm) for 3 h (P<0·01). In contrast, NK2R mRNA was unaltered in asthmatic lungs and dexamethasone treatment had no effect on the level of NK2R mRNA. These results suggest that chronic inflammation in asthma may result in increased NK1R gene expression and that this effect is reversed by glucocorticosteroids.

608 DOWN-REGULATION OF TACHYKININ RECEPTOR GENE EXPRESSION IN PATIENTS WITH INTERSTITIAL CYSTITIS IS MEDIATED BY MICRORNAS

2009 ◽  
Vol 8 (4) ◽  
pp. 272
Author(s):  
V. Sanchez-Freire ◽  
F.C. Burkhard ◽  
U.E. Studer ◽  
T.M. Kessler ◽  
A. Kuhn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Interstitial Cystitis ◽  
Receptor Gene ◽  
Down Regulation ◽  
Tachykinin Receptor ◽  
Receptor Gene Expression

Neurokinin receptor gene expression in substantia nigra: localization, regulation, and potential physiological significance

1995 ◽  
Vol 73 (7) ◽  
pp. 866-870 ◽  
Author(s):  
Michael J. Bannon ◽  
Christopher J. Whitty
Keyword(s):  
Gene Expression ◽  
Substance P ◽  
Substantia Nigra ◽  
Receptor Gene ◽  
Dopamine Neurons ◽  
Receptor Mrna ◽  
Neurokinin Receptor ◽  
Neurokinin 1 ◽  
Receptor Gene Expression ◽  
Human Substantia Nigra

Neurokinin receptor gene expression within the rat and human substantia nigra was examined in detail. In the rat, the relative abundances of nigral neurokinin receptor mRNAs were neurokinin 3 > neurokinin 1 [Formula: see text] neurokinin 2. High levels of neurokinin 3 mRNA were localized to dopamine neurons, as determined by dopamine cell lesions and colocalization with tyrosine hydroxylase mRNA. Stimulation of nigral neurokinin 3 receptors activated dopamine cells, as evidenced by increases in striatal dopamine metabolism and in a postsynaptic measure of dopamine neurotransmission (i.e., striatal substance P encoding mRNA). These and other anatomical and physiological data suggest that in the rat, substance P (released from striatonigral neurons) may act on nigral nondopamine cells through neurokinin 1 receptors, while the substance P cotransmitter neurokinin A may act preferentially on nigral dopamine neurons through neurokinin 3 receptors. Interestingly, high levels of neurokinin 1 (but not neurokinin 3) receptor mRNA are seen within human substantia nigra dopamine cells. Thus drugs interacting with neurokinin receptors may prove to be of value in the treatment of various neuropsychiatric disorders.Key words: neurokinin receptor, mRNA, dopamine, substantia nigra, human.

MICRORNAS MEDIATE DOWN-REGULATION OF TACHYKININ RECEPTOR GENE EXPRESSION IN INTERSTITIAL CYSTITIS/ PAINFUL BLADDER SYNDROME

2009 ◽  
Vol 181 (4S) ◽  
pp. 17-17
Author(s):  
Veronica Sanchez-Freire ◽  
Fiona C Burkhard ◽  
Urs E Studer ◽  
Thomas M. Kessler ◽  
Annette Kuhn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Interstitial Cystitis ◽  
Receptor Gene ◽  
Painful Bladder Syndrome ◽  
Down Regulation ◽  
Tachykinin Receptor ◽  
Painful Bladder ◽  
Receptor Gene Expression

scholarly journals Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus

2009 ◽  
Vol 7 (1) ◽  
pp. 77 ◽  
Author(s):  
Francisco M Pinto ◽  
C Oscar Pintado ◽  
Jocelyn N Pennefather ◽  
Eva Patak ◽  
Luz Candenas
Keyword(s):  
Gene Expression ◽  
Receptor Gene ◽  
Mouse Uterus ◽  
Ovarian Steroids ◽  
Tachykinin Receptor ◽  
Receptor Gene Expression

VIRAL RECEPTOR GENE EXPRESSION AND MYOCARDITIS DEVELOPMENT

2016 ◽  
Vol 30 (1) ◽  
Author(s):  
A. Runov ◽  
◽  
E Kurchakova ◽  
D Khaschevskaya ◽  
O Moiseeva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Receptor Gene ◽  
Viral Receptor ◽  
Receptor Gene Expression
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