scholarly journals Co60 Vitamin B12 Binding Capacity of Human Leukocytes

Blood ◽  
1962 ◽  
Vol 19 (2) ◽  
pp. 229-235 ◽  
Author(s):  
LEO M. MEYER ◽  
EUGENE P. CRONKITE ◽  
INEZ F. MILLER ◽  
CLAIRE W MULZAC ◽  
IRVING JONES
Keyword(s):  
Vitamin B12 ◽  
Human Serum ◽  
Polycythemia Vera ◽  
Binding Capacity ◽  
Chronic Myelocytic Leukemia ◽  
Nonspecific Binding ◽  
Two Phase ◽  
Intact Cells ◽  
Myelocytic Leukemia ◽  
Neutrophilic Leukocytes

Abstract 1. Mature neutrophilic leukocytes show the highest Co60B12 binding capacity. 2. Less mature granulocytes, "blast" forms and eosinophils have little or no Co60B12 binding capacity. 3. Disintegrated mature leukocytes from chronic myelocytic leukemia and polycythemia vera show higher B12 binding capacity than intact cells. 4. Mature leukocytes from patients with chronic myelocytic leukemia and polycythemia vera show a two-phase B12 curve suggesting specific and nonspecific binding, similar to that observed in human serum. 5. Disintegration products from mature neutrophilic leukocytes probably contribute largely to increased B12 binding capacity of serum in chronic myelocytic leukemia and polycythemia vera.

Ph1-negative chronic myelocytic leukemia (CML) with an unusual karyotype

1981 ◽  
Vol 3 (4) ◽  
pp. 347-351 ◽  
Author(s):  
Mabel Labal de Vinuesa ◽  
Irma Slavutsky ◽  
Juan Dupont ◽  
Catalina Bianchi de Di Risio ◽  
Sonia Brieux de Salum
Keyword(s):  
Chronic Myelocytic Leukemia ◽  
Myelocytic Leukemia

Oncogenes Involved in Chronic Myelocytic Leukemia

1985 ◽  
pp. 133-150
Author(s):  
Nora Heisterkamp ◽  
John R. Stephenson ◽  
Gerard Grosveld ◽  
Annelies De Klein ◽  
John Groffen
Keyword(s):  
Chronic Myelocytic Leukemia ◽  
Myelocytic Leukemia
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