Function of Chemical Synapses and the Quantal Theory of Transmitter Release

2019 ◽  
pp. 95-120
Author(s):  
Stephen D. Meriney ◽  
Erika E. Fanselow
Author(s):  
F.T. Llados ◽  
V. Krlho ◽  
G.D. Pappas

It Is known that Ca++ enters the muscle fiber at the junctional area during the action of the neurotransmitter, acetylcholine (ACh). Pappas and Rose demonstrated that following Intense stimulation, calcium deposits are found In the postsynaptic muscle membrane, Indicating the existence of calcium uptake In the postsynaptic area following ACh release. In addition to this calcium uptake, when mammal Ian skeletal muscles are exposed to a sustained action of the neurotransmitter, muscle damage develops. These same effects, l.e., Increased transmitter release, calcium uptake and finally muscle damage, can be obtained by Incubating the muscle with lonophore A23178.


1983 ◽  
Vol 3 (12) ◽  
pp. 2614-2620 ◽  
Author(s):  
J Camardo ◽  
E Proshansky ◽  
S Schacher

Sign in / Sign up

Export Citation Format

Share Document