External forcing and local response

2022 ◽  
pp. 143-210
Author(s):  
Bert Rudels
Keyword(s):  
External Forcing ◽  
Local Response

scholarly journals On Time Scales of Intrinsic Oscillations in the Climate System

Entropy ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 459
Author(s):  
Anastasios A. Tsonis ◽  
Geli Wang ◽  
Wenxu Lu ◽  
Sergey Kravtsov ◽  
Christopher Essex ◽  
...  
Keyword(s):  
Low Frequency ◽  
Milankovitch Cycles ◽  
Data Sets ◽  
External Forcing ◽  
Natural Oscillations ◽  
Climatic Oscillations ◽  
Slow Feature Analysis ◽  
Limited Length ◽  
Past Data ◽  
Cumulative Evidence

Proxy temperature data records featuring local time series, regional averages from areas all around the globe, as well as global averages, are analyzed using the Slow Feature Analysis (SFA) method. As explained in the paper, SFA is much more effective than the traditional Fourier analysis in identifying slow-varying (low-frequency) signals in data sets of a limited length. We find the existence of a striking gap from ~1000 to about ~20,000 years, which separates intrinsic climatic oscillations with periods ranging from ~ 60 years to ~1000 years, from the longer time-scale periodicities (20,000 yr +) involving external forcing associated with Milankovitch cycles. The absence of natural oscillations with periods within the gap is consistent with cumulative evidence based on past data analyses, as well as with earlier theoretical and modeling studies.

scholarly journals The Complexity of Drug Consumption Room Policy and Progress in Finland

2021 ◽  
pp. 009145092110025
Author(s):  
Ali Unlu ◽  
Fatih Demiroz ◽  
Tuukka Tammi ◽  
Pekka Hakkarainen
Keyword(s):  
Complexity Theory ◽  
Government Policy ◽  
Policy Process ◽  
Central Government ◽  
Drug Consumption ◽  
People Who Use Drugs ◽  
Local Response ◽  
Local Actors ◽  
Moral Frameworks ◽  
Drug Consumption Room

Drug consumption rooms (DCRs) have been established to reach high-risk people who use drugs (PWUDs) and reduce drug-associated harm. Despite effectiveness, their establishment requires strong advocacy and efforts since moral perspectives tend to prevail over health outcomes in many countries. DCRs have generally emerged as a local response to inadequate central government policy. Likewise, the initiative of the Municipality of Helsinki in 2018 opened up a discussion between central government, society, and local actors in Finland. This would be the first DCR in Finland, which makes the policy process and the progress of the initiative interesting for analysis. In this article, the identification of agents, structures of interactions, environmental challenges, and policy opportunities are analyzed within the framework of complexity theory. Our results show that the initiative faces policy barriers that have mainly arisen from the conceptualization of DCRs in moral frameworks that result in the prolongation of political and professional actors to take a position on DCRs.

scholarly journals SARS-CoV-2 RNA and antibodies in tear fluid

2021 ◽  
Vol 6 (1) ◽  
pp. e000733
Author(s):  
Astrid Muyldermans ◽  
Maria Bjerke ◽  
Thomas Demuyser ◽  
Deborah De Geyter ◽  
Ingrid Wybo ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Spike Protein ◽  
Tear Fluid ◽  
Local Response ◽  
Schirmer Test ◽  
Humoral Immune ◽  
Non Invasive ◽  
Reverse Transcription Pcr ◽  
Ocular Symptoms

Background/aimsSARS-CoV-2 is highly contagious. More evidence concerning extrapulmonary transmission routes such as the eyes is urgently needed. Although the humoral immune response is important in the viral containment, the local response in tears has not yet been studied. The aim of our study was twofold: to assess the prevalence of both SARS-CoV-2 RNA and antibodies in tear fluid.MethodsIn a first series, nasopharyngeal sampling and tear sampling by Schirmer test strips were performed in 26 acutely ill patients with COVID-19 to assess the presence of SARS-CoV-2 RNA by reverse transcription PCR. In a second series, IgG and IgA responses to SARS-CoV-2 spike protein in serum and tear fluid of convalescent individuals (n=22) were compared with control individuals (n=15) by ELISA.ResultsSARS-CoV-2 RNA was detected in tears of 7/26 (26.9%) patients with COVID-19. None of them had ocular symptoms. Convalescent individuals displayed a significant higher ratio of IgG (p<0.0001) and IgA (p=0.0068) in tears compared with control individuals. A sensitivity of 77.3% and specificity of 93.3% was observed for IgG, and 59.1% and 100% for IgA.ConclusionsOur results demonstrate the presence of SARS-CoV-2 RNA and a local IgG and IgA immune response in tear fluid. These data confirm the possibility of SARS-CoV-2 transmission through tear fluid and the importance of the eye as a first defence against SARS-CoV-2, indicating the potential of tears as a non-invasive surrogate for serum in monitoring the host immune response.

scholarly journals Local response to the COVID‐19 pandemic: The case of Nepal

2021 ◽  
Author(s):  
Raju Mainali ◽  
Mehmet S. Tosun ◽  
Serdar Yilmaz
Keyword(s):  
Local Response

scholarly journals Systematic Review of the Role of BCG in the Treatment of Urothelial Carcinoma of the Prostatic Urethra

2021 ◽  
pp. 1-8
Author(s):  
Oliver Patschan ◽  
Philippe E. Spiess ◽  
George N. Thalmann ◽  
Joan Palou Redorta ◽  
Georgios Gakis
Keyword(s):  
Side Effects ◽  
Urothelial Carcinoma ◽  
Evidence Synthesis ◽  
Tnm Classification ◽  
Transitional Cell ◽  
Prostatic Urethra ◽  
Local Response ◽  
Pubmed Database ◽  
Bcg Therapy ◽  
Tumor Stages

BACKGROUND: In patients with non-invasive urothelial carcinoma of the prostatic urethra (PUC), treatment with Bacillus Calmette-Guárin (BCG) could be beneficial. OBJECTIVE: To assess the response rates to BCG in the different tumor stages, to describe the clinical impact of transurethral resection of the prostate (TURP) before BCG treatment, and to review the side effects of BCG treatment for PUC. METHODS: A systematic search was conducted using the PubMed database to identify original studies between 1977 and 2019 reporting on PUC and BCG. RESULTS: Of a total of 865 studies, ten were considered for evidence synthesis. An indication for BCG treatment was found in non-stromal invasive stages (Tis pu, Tis pd) and in stromal infiltrating cases (T1) of primary and secondary PUC when transitional cell carcinoma was the histology of origin. Studies including patients treated with TURP before BCG showed a better local response in the prostatic urethra with a higher DFS (80–100% vs. 63–89%) and PFS (90–100% vs. 75–94%) than patients in studies in which no TURP was performed. However, this difference in recurrence and progression in the prostate neither affected the total PFS (57–75% vs. 58–93%), nor the disease specific survival (70–100% vs. 66–100%). CONCLUSIONS: The use of resection loop biopsies of the prostatic urethra in appropriate cases during the primary work-up for suspected PUC, as well as the use of the current TNM classification for PUC, need to be improved. BCG therapy for non-stromal invasive stages of PUC show a good local response. Local response is further improved by a TURP before BCG therapy, although the overall prognosis does not seem to be affected. Further evidence for BCG treatment in the rare cases of stromal invasive PUC is needed. Specific side effects of BCG treatment for PUC are not reported.

scholarly journals Spatio-temporal integration in plant tropisms

2019 ◽  
Vol 16 (154) ◽  
pp. 20190038 ◽  
Author(s):  
Yasmine Meroz ◽  
Renaud Bastien ◽  
L. Mahadevan
Keyword(s):  
Response Function ◽  
Shoot Growth ◽  
Analytic Solution ◽  
Temporal Integration ◽  
Time Varying ◽  
Local Response ◽  
History Of ◽  
Non Local ◽  
Spatio Temporal ◽  
Plant Shoots

Tropisms, growth-driven responses to environmental stimuli, cause plant organs to respond in space and time and reorient themselves. Classical experiments from nearly a century ago reveal that plant shoots respond to the integrated history of light and gravity stimuli rather than just responding instantaneously. We introduce a temporally non-local response function for the dynamics of shoot growth formulated as an integro-differential equation whose solution allows us to qualitatively reproduce experimental observations associated with intermittent and unsteady stimuli. Furthermore, an analytic solution for the case of a pulse stimulus expresses the response function as a function of experimentally tractable variables, which we calculate for the case of the phototropic response of Arabidopsis hypocotyls. All together, our model enables us to predict tropic responses to time-varying stimuli, manifested in temporal integration phenomena, and sets the stage for the incorporation of additional effects such as multiple stimuli, gravitational sagging, etc.

Role of Local Response in Ion Solvation: Born Theory and Beyond

2016 ◽  
Vol 120 (26) ◽  
pp. 6238-6249 ◽  
Author(s):  
Richard C. Remsing ◽  
John D. Weeks
Keyword(s):  
Ion Solvation ◽  
Local Response
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