Resveratrol and brain mitochondria

2021 ◽  
pp. 645-687
Author(s):  
Patrícia Coelho ◽  
Ana Cristina Carvalho Rego
Keyword(s):  
Brain Mitochondria

scholarly journals Mitochondrial Mistranslation in Brain Provokes a Metabolic Response Which Mitigates the Age-Associated Decline in Mitochondrial Gene Expression

2021 ◽  
Vol 22 (5) ◽  
pp. 2746
Author(s):  
Dimitri Shcherbakov ◽  
Reda Juskeviciene ◽  
Adrián Cortés Sanchón ◽  
Margarita Brilkova ◽  
Hubert Rehrauer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Response ◽  
Mitochondrial Gene ◽  
Tca Cycle ◽  
Brain Mitochondria ◽  
Mitochondrial Gene Expression ◽  
Rna Seq ◽  
The Tca Cycle ◽  
Neurological Phenotype

Mitochondrial misreading, conferred by mutation V338Y in mitoribosomal protein Mrps5, in-vivo is associated with a subtle neurological phenotype. Brain mitochondria of homozygous knock-in mutant Mrps5V338Y/V338Y mice show decreased oxygen consumption and reduced ATP levels. Using a combination of unbiased RNA-Seq with untargeted metabolomics, we here demonstrate a concerted response, which alleviates the impaired functionality of OXPHOS complexes in Mrps5 mutant mice. This concerted response mitigates the age-associated decline in mitochondrial gene expression and compensates for impaired respiration by transcriptional upregulation of OXPHOS components together with anaplerotic replenishment of the TCA cycle (pyruvate, 2-ketoglutarate).

scholarly journals Electrophysiological characterization of contact sites in brain mitochondria.

1990 ◽  
Vol 265 (2) ◽  
pp. 908-913
Author(s):  
O Moran ◽  
G Sandri ◽  
E Panfili ◽  
W Stühmer ◽  
M C Sorgato
Keyword(s):  
Brain Mitochondria ◽  
Contact Sites ◽  
Electrophysiological Characterization

scholarly journals Some interrelated properties of A and B form monoamine oxidase in monkey brain mitochondria.

1984 ◽  
Vol 34 (3) ◽  
pp. 327-334 ◽  
Author(s):  
Toru EGASHIRA ◽  
Toshinori YAMAMOTO ◽  
Yasumitsu YAMANAKA
Keyword(s):  
Monoamine Oxidase ◽  
Brain Mitochondria ◽  
Monkey Brain
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