Revealing nervous and cardiac system interactions by iPSC-Based platforms

2022 ◽  
pp. 1-28
Author(s):  
Ozlem Mutlu Burnaz ◽  
Esra Cagavi
Keyword(s):  
Cardiac System

scholarly journals Cyclin D1: A Golden Gene in Cancer, Cardiotoxicity, and Cardioprotection

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Habib Haybar ◽  
Mehhdi Shahrouzian ◽  
Zahra Gatavizadeh ◽  
Najmaldin Saki ◽  
Mahmood Maniati ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Poor Prognosis ◽  
Therapeutic Response ◽  
Single Injection ◽  
Cdk Inhibitors ◽  
Cyclin D ◽  
Cyclin Dependent Kinase ◽  
Hypertrophic Growth ◽  
Cardiac System ◽  
Treatment Responses

Objective: Cyclin D1 is an essential protein that acts as a mitogenic sensor. In this manuscript, we discuss the importance of cyclin D1 in oncology and cardio-oncology, and we challenge the prognostic and therapeutic response values of cyclin D1 to figure out if it can be a beneficial marker. We also discuss the agents and microRNAs that can be used as a potential therapeutic approach via regulating cyclin D1 expression in oncology and cardio-oncology. Discussion: Clinical significance of cyclin D1 is defined not only in several cancers such as breast cancer, melanoma, and glioblastoma but also in cardiomyocyte regeneration and cardiac hypertrophic growth. Several studies have indicated that the injection of cardiotoxic agents such as doxorubicin (DOX) induces damage to the cardiac system and increases cyclin D expression at single injection, which might be related to DXO-mediated damage in the adult heart. However, cyclin D1 overexpression leads to hypertrophic growth of cardiomyocytes, and cyclin-dependent kinase (CDK)) inhibitors such as p16 do not inhibit the hypertrophic growth of cardiomyocytes. Thus, the reaction is CDK-independent. Conclusions: Cyclin D1 overexpression is positively correlated with tumor progression, treatment response, cardiotoxicity, and poor prognosis. Cyclin D1 expression has an important role in cardiac hypertrophy, and it can be a promising marker in monitoring cardiomyocyte treatment responses, cardioprotection, and cardiotoxicity. Finally, cyclin D1 plays an important role in hypertrophic growth of cardiomyocytes via a novel mechanism. Given all these pieces of evidence, cyclin D1 can be introduced as a favorable biomarker in future cardiology and cardio-oncology.

scholarly journals Perioperative sequential monitoring of hemodynamic parameters in patients with pheochromocytoma using the Non-Invasive Cardiac System (NICaS)

2014 ◽  
Vol 61 (6) ◽  
pp. 571-575 ◽  
Author(s):  
Yayoi Matsuda ◽  
Hisaya Kawate ◽  
Shingo Shimada ◽  
Chitose Matsuzaki ◽  
Hiromi Nagata ◽  
...  
Keyword(s):  
Hemodynamic Parameters ◽  
Non Invasive ◽  
Cardiac System

The Cardiac System

2017 ◽  
Author(s):  
David C Mauchley
Keyword(s):  
Sinoatrial Node ◽  
Circulatory System ◽  
Atrioventricular Node ◽  
Atrial Septum ◽  
The Body ◽  
Arterial System ◽  
Pulmonic Valve ◽  
Anatomy And Physiology ◽  
Cardiac System ◽  
Cardiac Operations

The circulatory system, which consists of the heart, arterial system, venous system, and lymphatics, constitutes a complicated network of vessels and ducts that are responsible for the delivery of oxygenated blood to the body and return of deoxygenated blood to the heart and lungs. The heart is at the center of the circulatory system, and its pumping mechanism provides energy and nutrition to all organs in the body. This review focuses on the anatomy and physiology of the heart and describes anatomic details that are important to the planning of many common cardiac operations.    This review contains 28 figures, and 25 references. Key words: aortic root, aortic valve, atrial septum, atrioventricular node, coronary artery, fibrous skeleton of heart, mitral valve, myocardium, pericardium, pulmonic valve, sinoatrial node, tricuspid valve, ventricular septum 

The Cardiac System

2017 ◽  
pp. 223-251
Author(s):  
Helene Smith-Gabai ◽  
Suzanne Holm
Keyword(s):  
Cardiac System

Cardiac System

2006 ◽  
pp. 450-507
Author(s):  
Harvey A. Ziessman ◽  
Janis P. O'Malley ◽  
James H. Thrall
Keyword(s):  
Cardiac System

Extracorporeal Membrane Oxygenation: Current Use and Future Directions

1990 ◽  
Vol 1 (2) ◽  
pp. 348-364 ◽  
Author(s):  
Beth Kaplan McDermott ◽  
Martha A. Q. Curley
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Pediatric Population ◽  
Critical Care Nursing ◽  
Nursing Management ◽  
Ecmo Patient ◽  
Future Directions ◽  
Membrane Oxygenation ◽  
Critically Ill Neonates ◽  
Cardiac System

Extracorporeal membrane oxygenation (ECMO) is the process of using prolonged cardiopulmonary bypass to support patients with reversible respiratory and/or cardiac failure who are refractory to maximal conventional therapy. This process has been used extensively for critically ill neonates, with encouraging results. The use of ECMO in the pediatric population has been limited but is increasing. The history, mechanics, and current applications of ECMO are discussed in this article. Critical care nursing management of the pediatric or neonatal ECMO patient focuses on optimizing recovery of the pulmonary and/or cardiac system while preventing complications. A case study of a pediatric ECMO patient is presented which illustrates the complex nursing care issues related to use of this intervention. Future directions for ECMO are addressed

scholarly journals Causal Scale of Rotors in a Cardiac System

2018 ◽  
Vol 6 ◽  
Author(s):  
Hiroshi Ashikaga ◽  
Francisco Prieto-Castrillo ◽  
Mari Kawakatsu ◽  
Nima Dehghani
Keyword(s):  
Cardiac System
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