This article reviews current surgical techniques for a deviated septum and, in particular, focuses on the comparison of conventional and endoscopic approaches to septoplasty. Relevant issues of the anatomy and physiology of the nasal septum affecting the course of the comorbidities of the nasal cavity and the surrounding structures are discussed. The conventional and endoscopic approaches to septoplasty, indications, the benefits and drawbacks of each technique are addressed. The authors highlight the spectrum of the potential surgical procedures to the surrounding structures with the correction of the deviated septum as the first step. This surgical strategy in patients with the combined disorders of the internal structures of the nasal cavity is accounted for by the favorable course of the chronic conditions of the nasal cavity in the postoperative period and the possibility for providing adequate care for the nasal cavity. This article describes authors’ experience with the surgical correction of the deviated septum using endoscopic approach at all steps of the surgery. Clear advantages of this techniques in terms of both intraoperative accuracy and postoperative care for the nasal cavity are uncovered. KEYWORDS: endoscopic septoplasty, nasal septum, rhinological patients, conus beam computed tomography of the paranasal sinuses, nasal tumor. FOR CITATION: Karpishchenko S.A., Vereshchagina O.E., Teplova E.O. Clinical experience with endoscopic septoplasty. Russian Medical Inquiry. 2020;4(4):254–258. DOI: 10.32364/2587-6821-2020-4-4-254-258.