Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond

2018 ◽  
pp. 117-134 ◽  
Author(s):  
Jacob Valentine ◽  
Ali Tavassoli
Keyword(s):  
Cyclic Peptide ◽  
Peptide Libraries

ChemInform Abstract: Head-to-Tail Cyclic Peptides and Cyclic Peptide Libraries

ChemInform ◽  
2000 ◽  
Vol 31 (47) ◽  
pp. no-no
Author(s):  
Arno F. Spatola ◽  
Peteris Romanovskis
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Peptide Libraries

Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries

2020 ◽  
Vol 31 (9) ◽  
pp. 2085-2091
Author(s):  
Xuejun Zheng ◽  
Weidong Liu ◽  
Ziyan Liu ◽  
Yibing Zhao ◽  
Chuanliu Wu
Keyword(s):  
Cyclic Peptide ◽  
Peptide Libraries

scholarly journals Yeast two-hybrid screening of cyclic peptide libraries using a combination of random and PI-deconvolution pooling strategies

2012 ◽  
Vol 25 (9) ◽  
pp. 453-464 ◽  
Author(s):  
K. Barreto ◽  
A. Aparicio ◽  
V. M. Bharathikumar ◽  
J. F. DeCoteau ◽  
C. R. Geyer
Keyword(s):  
Cyclic Peptide ◽  
Peptide Libraries ◽  
Yeast Two Hybrid ◽  
Pooling Strategies ◽  
Two Hybrid ◽  
Hybrid Screening

scholarly journals Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

ACS Omega ◽  
2021 ◽  
Author(s):  
Remi Kinoshita ◽  
Ikko Kozaki ◽  
Kazunori Shimizu ◽  
Takahiro Shibata ◽  
Akihito Ochiai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Substitution ◽  
Cyclic Peptide ◽  
Peptide Libraries ◽  
Antagonist Activity

Cyclic, Cell-Penetrating Peptides Tailor-Made for the Creation of Peptide Libraries with Intrinsic Cell Permeability

2020 ◽  
Author(s):  
Nicolas A. Abrigo ◽  
Kara Dods ◽  
Koushambi Mitra ◽  
Kaylee Newcomb ◽  
Anthony Le ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Cell Penetrating Peptides ◽  
Peptide Libraries ◽  
Cell Permeability ◽  
Side Chain ◽  
High Affinity ◽  
Cell Penetrating ◽  
The Creation ◽  
Intracellular Targets ◽  
Macrocyclic Peptide

<p>The discovery of high-affinity peptides to many intracellular targets has become feasible through the development of diverse macrocyclic peptide libraries. But lack of cell permeability is a key feature hampering the use of these peptides as therapeutics. Here, we develop a set of small, cyclic peptide carriers that efficiently carry cargoes into the cytosol. These peptides are cyclized via side-chain alkylation, which makes them ideal for the creation of diverse mRNA or phage-displayed libraries with intrinsic cell permeability.</p>

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