Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2009.04.011 ◽

2009 ◽

Vol 486 (2) ◽

pp. 155-164 ◽

Author(s):

Rodrigo G. Ducati ◽

Diógenes S. Santos ◽

Luiz A. Basso

Keyword(s):

Mycobacterium Tuberculosis ◽

Substrate Specificity ◽

Purine Nucleoside Phosphorylase ◽

Kinetic Mechanism ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase

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Purine Nucleoside Phosphorylase as a Molecular Target to Develop Active Compounds Against Mycobacterium Tuberculosis

International Review of Biophysical Chemistry (IREBIC) ◽

10.15866/irebic.v1i1.1490 ◽

2010 ◽

Vol 1 (1) ◽

pp. 34

Author(s):

Rodrigo G. Ducati ◽

André A. Souto ◽

Rafael A. Caceres ◽

Walter F. De Azevedo ◽

Luiz A. Basso ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Purine Nucleoside Phosphorylase ◽

Molecular Target ◽

Purine Nucleoside ◽

Active Compounds ◽

Nucleoside Phosphorylase

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Substrate Specificity of a Purine Nucleoside Phosphorylase from Aeromonas hydrophila Toward 6-Substituted Purines and its Use as a Biocatalyst in the Synthesis of the Corresponding Ribonucleosides

Current Organic Chemistry ◽

10.2174/1385272819666150807191212 ◽

2015 ◽

Vol 19 (22) ◽

pp. 2220-2225 ◽

Author(s):

Daniela Ubiali ◽

Carlo Morelli ◽

Marco Rabuffetti ◽

Giulia Cattaneo ◽

Immacolata Serra ◽

...

Keyword(s):

Substrate Specificity ◽

Aeromonas Hydrophila ◽

Purine Nucleoside Phosphorylase ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase

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Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase

Biochemistry ◽

10.1021/acs.biochem.5b01347 ◽

2016 ◽

Vol 55 (14) ◽

pp. 2153-2162 ◽

Author(s):

Geir Villy Isaksen ◽

Kathrin Helen Hopmann ◽

Johan Åqvist ◽

Bjørn Olav Brandsdal

Keyword(s):

Substrate Specificity ◽

Computer Simulations ◽

Purine Nucleoside Phosphorylase ◽

Bond Cleavage ◽

Purine Nucleoside ◽

Glycosidic Bond ◽

Nucleoside Phosphorylase ◽

Glycosidic Bond Cleavage

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Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.05.009 ◽

2010 ◽

Vol 18 (13) ◽

pp. 4769-4774 ◽

Author(s):

Rodrigo G. Ducati ◽

Luiz A. Basso ◽

Diógenes S. Santos ◽

Walter F. de Azevedo

Keyword(s):

Mycobacterium Tuberculosis ◽

Purine Nucleoside Phosphorylase ◽

Docking Studies ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase

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Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir

Biochimie ◽

10.1016/j.biochi.2011.10.003 ◽

2012 ◽

Vol 94 (1) ◽

pp. 155-165 ◽

Author(s):

Rafael A. Caceres ◽

Luís F.S.M. Timmers ◽

Rodrigo G. Ducati ◽

Diego O.N. da Silva ◽

Luiz A. Basso ◽

...

Keyword(s):

Crystal Structure ◽

Molecular Dynamics ◽

Mycobacterium Tuberculosis ◽

Purine Nucleoside Phosphorylase ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase

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Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ◽

10.1016/s0167-4838(02)00218-2 ◽

2002 ◽

Vol 1596 (2) ◽

pp. 293-317 ◽

Author(s):

Agnieszka Bzowska

Keyword(s):

Purine Nucleoside Phosphorylase ◽

Kinetic Mechanism ◽

Purine Nucleoside ◽

Oligomeric State ◽

Nucleoside Phosphorylase ◽

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Purine nucleoside phosphorylase. Kinetic mechanism of the enzyme from calf spleen.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42523-9 ◽

1992 ◽

Vol 267 (11) ◽

pp. 7342-7351

Author(s):

D.J. Porter

Keyword(s):

Purine Nucleoside Phosphorylase ◽

Kinetic Mechanism ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase

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Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase

Analytica Chimica Acta ◽

10.1016/j.aca.2016.09.025 ◽

2016 ◽

Vol 943 ◽

pp. 89-97 ◽

Author(s):

Giulia Cattaneo ◽

Daniela Ubiali ◽

Enrica Calleri ◽

Marco Rabuffetti ◽

Georg C. Höfner ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Purine Nucleoside Phosphorylase ◽

Enzymatic Assay ◽

Purine Nucleoside ◽

Selective Inhibitors ◽

Nucleoside Phosphorylase ◽

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Faculty Opinions recommendation of L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1097544.553622 ◽

2008 ◽

Author(s):

Wayne Guida

Keyword(s):

Transition State ◽

Purine Nucleoside Phosphorylase ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase ◽

Transition State Analogue ◽

Transition State Analogue Inhibitors

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Faculty Opinions recommendation of Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733476941.793549593 ◽

2018 ◽

Author(s):

Andrey Kovalevsky ◽

Steven Dajnowicz

Keyword(s):

Purine Nucleoside Phosphorylase ◽

Isotope Effects ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase

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